双氯芬酸钾与泼尼松龙对症状性不可逆牙髓炎病例牙髓炎后疼痛和牙髓白细胞介素-8表达的影响:一项随机安慰剂对照试验。

IF 3.5 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
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引用次数: 0

摘要

目的:这项前瞻性、随机、双盲临床试验研究了双氯芬酸钾、泼尼松龙和安慰剂作为口服前药对不可逆性牙髓炎患者牙髓治疗后疼痛和牙髓白细胞介素(IL)-8表达的影响:36名接受传统牙髓治疗的患者被分为三组(12人)。在牙髓腔准备后采集牙髓血样并保存,直到使用 ELISA 分析 IL-8 的定量。根管治疗后的疼痛采用视觉模拟量表进行评分。结果数据采用单因素方差分析、Kruskal-Wallis、Friedman's、Dunn's、Chi-square 和 Fisher's 精确检验以及 Spearman 相关系数进行统计分析。显著性水平(α)定为 0.05:除术前疼痛评分外,各组的基线特征相似(P > .05)。牙髓术后即刻疼痛评分在各组之间存在显著差异(P < .05),其中安慰剂组的评分最高。各组在术后 6 小时和 12 小时的疼痛评分无明显差异(P > .05)。此外,牙髓术后疼痛的发生率和 IL-8 的平均水平在三组之间没有明显差异(P > .05):结论:术前用药对根管治疗后即刻疼痛强度的影响是唯一的,对后期时间点、根管治疗后疼痛发生率或牙髓IL-8水平没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of Diclofenac Potassium versus Prednisolone on Postendodontic Pain and Pulpal Interleukin-8 Expression in Symptomatic Irreversible Pulpitis Cases: A Randomized Placebo-controlled Trial

Aim

This prospective, randomized, double-blind clinical trial investigated the impact of diclofenac potassium, prednisolone, and placebo as oral premedication on postendodontic pain and pulpal interleukin (IL)-8 expression in patients with irreversible pulpitis.

Methods

Thirty-six patients undergoing conventional endodontic treatment were assigned into one of 3 groups (n = 12). Pulpal blood samples were taken after access cavity preparation and stored until they were analyzed using enzyme-linked immunosorbent asssay for quantification of IL-8. Postendodontic pain was scored using the visual analogue scale. Outcome data were statistically analyzed using one-way analysis of variance, Kruskal-Wallis, Friedman's, Dunn's, Chi-square, and Fisher's exact tests and Spearman's correlation coefficient. The significance level (α) was set at 0.05.

Results

Apart from preoperative pain scores, all groups had similar baseline characteristics (P > .05). Immediate postendodontic pain scores had a significant difference between all groups (P < .05) where placebo group showed the highest score. There was no significant difference between all groups at 6 and 12 hours postoperatively (P > .05). Furthermore, there was no significant difference in the incidence of postendodontic pain and in mean IL-8 levels between the 3 groups (P > .05).

Conclusions

The only impact the premedications had was on the immediate postendodontic pain intensity, and they had no influence on the later time points, incidence of postendodontic pain or pulpal IL-8 levels.

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来源期刊
Journal of endodontics
Journal of endodontics 医学-牙科与口腔外科
CiteScore
8.80
自引率
9.50%
发文量
224
审稿时长
42 days
期刊介绍: The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
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