龈下应用益生菌作为牙周炎洗牙和根面平整术的辅助疗法的疗效和活力。

Q3 Dentistry
Indian Journal of Dental Research Pub Date : 2024-01-01 Epub Date: 2024-06-20 DOI:10.4103/ijdr.ijdr_533_23
Mariam Poulose, Dnyaneshwari Gujar, Suneeta Panicker, Shreya Rokade, Meghana Guruprasad, Dharmarajan Gopalakrishnan
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引用次数: 0

摘要

目的:本研究旨在比较龈下涂抹益生菌作为洗牙和根面平整术(SRP)的辅助手段与单纯SRP对牙周炎患者的疗效:选取至少两颗对侧牙齿探诊袋深度(PPD)为5-7毫米的牙周炎患者作为研究对象,将其随机分配到试验组(n = 31)和对照组(n = 31),试验组在进行洗牙和根面平整术的同时在龈下涂抹益生菌膏,对照组仅进行洗牙和根面平整术。在基线和 12 周后对两组的临床参数进行了评估。在基线、第 4 天和第 8 天对试验组的益生菌存活率进行了评估:在组内和组间比较中,所有临床参数在基线和 12 周后均有显著统计学差异,试验组的改善幅度更大。微生物学评估显示,试验组在基线、第 4 天和第 8 天的平均菌落形成单位(CFU)分别为 38.39 ± 7.76、7.25 ± 2.72 和 1.57 ± 1.29。从基线到第 8 天,随着时间的延长,平均 CFUs 明显减少:益生菌在牙周袋中的存活时间最长为放置后 8 天,但即使在 12 周后,所有临床指标仍有稳定的改善,这表明益生菌具有长期疗效。因此,市售益生菌与 SRP 结合使用可证明是治疗牙周炎的一种廉价方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and Viability of Subgingival Application of Probiotics as an Adjunct to Scaling and Root Planing in Periodontitis.

Aim: This study aimed to compare the efficacy of subgingivally applied probiotics as an adjunct to scaling and root planing (SRP) vs SRP alone in patients with periodontitis.

Materials and methods: Patients diagnosed with periodontitis, with probing pocket depth (PPD) of 5-7 mm on at least two teeth on contralateral sites, were selected for the study and randomly allocated to the test group (n = 31) who underwent SRP along with subgingival application of probiotic paste and the control group (n = 31) who underwent only SRP. Clinical parameters were evaluated in both groups at baseline and after 12 weeks. The viability of probiotic bacteria was evaluated in the test group at baseline, day 4 and day 8.

Results: All clinical parameters showed a statistically significant difference between baseline and 12 weeks on intragroup and intergroup comparison, with a greater improvement in the test group. Microbiological evaluation showed that the mean colony-forming units (CFUs) in the test group were 38.39 ± 7.76, 7.25 ± 2.72 and 1.57 ± 1.29 at baseline, day 4 and day 8, respectively. The mean CFUs significantly reduced with an increase in time from baseline to 8-day time interval.

Conclusion: It was seen that the probiotic bacteria remained viable in the periodontal pocket for up to 8 days after placement, but stable improvements were seen in all clinical parameters even at 12 weeks, indicating its prolonged efficacy. Thus, commercially available probiotics can prove to be an inexpensive method to treat periodontitis when combined with SRP.

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来源期刊
Indian Journal of Dental Research
Indian Journal of Dental Research Dentistry-Dentistry (all)
CiteScore
1.80
自引率
0.00%
发文量
80
审稿时长
38 weeks
期刊介绍: Indian Journal of Dental Research (IJDR) is the official publication of the Indian Society for Dental Research (ISDR), India section of the International Association for Dental Research (IADR), published quarterly. IJDR publishes scientific papers on well designed and controlled original research involving orodental sciences. Papers may also include reports on unusual and interesting case presentations and invited review papers on significant topics.
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