肿瘤学中的个性化疗法:黑色素瘤是分子靶向治疗方法的典范。

IF 4.2 3区 医学 Q2 ONCOLOGY
Clinical & Experimental Metastasis Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI:10.1007/s10585-024-10291-5
Kevin B Kim
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引用次数: 0

摘要

近几十年来,由于对癌症生物学、免疫学和基因构成的认识不断进步,系统性癌症治疗领域发生了显著变化。因此,晚期癌症患者的生存率达到了以前无法企及的水平。个性化癌症疗法的目标是根据每位患者肿瘤的独特基因和/或表观遗传特征定制药物治疗方案,从而提高临床疗效。这种方法旨在减少无效治疗常见的副作用。基因测序和分子细胞遗传学的进步有助于确定致癌突变和表观遗传学异常,从而开发出特定的分子疗法。这篇综述文章重点介绍了靶向分子疗法在治疗恶性黑色素瘤方面取得的进展和成功,诠释了个性化癌症治疗的概念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Personalized therapy in oncology: melanoma as a paradigm for molecular-targeted treatment approaches.

Personalized therapy in oncology: melanoma as a paradigm for molecular-targeted treatment approaches.

In recent decades, the field of systemic cancer treatment has seen remarkable changes due to advancements in the understanding of cancer's biology, immunology, and genetic makeup. As a result, individuals with late-stage cancers are now achieving survival rates that were previously unattainable. The goal of personalized cancer therapy is to enhance clinical outcomes by customizing drug treatments to suit the unique genetic and/or epigenetic profiles of each patient's tumor. This approach aims to reduce the side effects commonly associated with ineffective treatments. Advances in genetic sequencing and molecular cytogenetics have been instrumental in identifying cancer-driving mutations and epigenetic irregularities, leading to the development of specific molecular therapies. This review article highlights the progress and success of targeted molecular therapies in treating malignant melanoma, illustrating the concept of personalized cancer treatment.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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