无干扰素丙型肝炎治疗会增加感染艾滋病毒的黑人退伍军人患动脉粥样硬化性心血管疾病风险的替代物。

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2024-07-15 Epub Date: 2024-06-27 DOI:10.1097/QAD.0000000000003900

Poonam Mathur, Habib O Ramadhani, Roman Kaplan, Kristen A Stafford, Amanda Theppote, Eleanor Wilson

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引用次数: 0

摘要

感染艾滋病毒（VLWH）和丙型肝炎病毒（HCV）的退伍军人罹患心血管疾病（CVD）的风险增加。丙型肝炎病毒（HCV）治愈是否会降低这一人群的心血管疾病风险尚不清楚。我们评估了 VLWH 在 HCV 治愈 18 个月后作为心血管疾病风险替代指标的低密度脂蛋白（LDL）的变化。我们发现，在晚期纤维化的 VLWH 中，低密度脂蛋白明显升高，这可能会增加心血管疾病的风险。可能需要降低低密度脂蛋白阈值，以便在HCV治愈后对VLWH启动降脂治疗。

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Interferon-free hepatitis C treatment increases a surrogate of atherosclerotic cardiovascular disease risk in Black veterans living with HIV.

Veterans living with HIV (VLWH) and hepatitis C virus (HCV) co-infection have an exacerbated risk of cardiovascular disease (CVD). It is unknown if HCV cure reduces CVD risk in this population. We evaluated changes in low-density lipoprotein (LDL), as a surrogate of CVD risk, 18 months after HCV cure in VLWH. We found significant increases in LDL in VLWH with advanced fibrosis, potentially increasing CVD risk. Lower LDL thresholds to initiate lipid-lowering therapies in VLWH after HCV cure may be warranted.

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.