Tetradium trichotomum树枝和树叶中的化学成分。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-25 DOI:10.1080/10286020.2024.2363403

引用次数: 0

摘要

从三疣梭子蟹（Tetradium trichotomum）的枝叶中分离出了 12 种化合物，其中包括 4 种新化合物：6β,7α-limondiol (1) 和 19-hydroxyisoobacunoate diosphenol (2)、N-苯甲酰基 3-prenyltyramine (9) 和 9-O-methyl integrifoliodiol (12)。通过质谱、核磁共振和单晶 X 射线衍射分析阐明了这些化合物的结构。化合物 1、6、8、9 和 12 在体外对 ConA 诱导的 T 淋巴细胞和 LPS 诱导的 B 细胞的增殖具有免疫抑制活性。

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Chemical constituents from the twigs with leaves of Tetradium trichotomum

Twelve compounds, comprising of four new ones, 6β,7α-limondiol (1) and ethyl 19-hydroxyisoobacunoate diosphenol (2), N-benzoyl 3-prenyltyramine (9) and 9-O-methyl integrifoliodiol (12), were isolated from the twigs with leaves of Tetradium trichotomum. The structures were elucidated by analysis of MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 6, 8, 9 and 12 exhibited immunosuppressive activities in vitro against the proliferation of ConA-induced T lymphocytes and LPS-induced B cells.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.