Vera Sumual, Reynardi Larope Sutanto, Angelina Patricia Chandra
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Random-effects meta-analysis was performed to estimate the pooled OR along with their 95% CIs.</p><p><strong>Results: </strong>This review included 5 cohort studies involving 2048 babies. A higher incidence of ROP was observed in infants born through vaginal delivery compared with caesarean section. Meta-analysis showed that C-section decreased the unadjusted odds of having ROP infants by 46% with low heterogeneity (OR 0.54 (95% CI 0.40 to 0.73); I<sup>2</sup>=40.73%). However, pooled adjusted effects were statistically insignificant with moderate heterogeneity (adjusted OR 0.59 (95% CI 0.28 to 1.23); I<sup>2</sup>=70.51%), possibly stemming from multiple variations in the controlled variables of each study.</p><p><strong>Conclusion: </strong>Despite varying statistical significance, our findings underscore the crucial need to comprehend the influence of delivery mode on neonatal ophthalmic outcomes. 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引用次数: 0
摘要
背景：早产儿视网膜病变（ROP早产儿视网膜病变（ROP）是全球儿童失明的主要原因。及时诊断和治疗对早产儿视网膜病变的治疗至关重要。因此，识别突出的风险因素有助于立即采取行动。在各种风险因素中，分娩方式对早产儿视网膜病变的影响仍不明确。因此，本研究旨在评估不同分娩方式对早产儿视网膜病变发病率的影响：在PubMed、ProQuest、EBSCOHost和Cochrane数据库中进行了全面的文献检索，以评估分娩方式--阴道分娩或剖腹产（c-section）--与自开始至2023年12月的ROP发病率之间的关系。随机效应荟萃分析估算了汇总的OR及其95% CI：该综述包括 5 项队列研究，涉及 2048 名婴儿。与剖腹产相比，阴道分娩婴儿的视网膜病变发生率更高。Meta 分析表明，剖腹产降低了 46% 的视网膜病变婴儿的未调整几率，异质性较低（OR 0.54 (95% CI 0.40 to 0.73)；I2=40.73%）。然而，汇总调整后的效果在统计学上并不显著，且存在中度异质性（调整后 OR 0.59 (95% CI 0.28 至 1.23)；I2=70.51%），这可能是由于每项研究的控制变量存在多种差异：尽管统计意义不尽相同，但我们的研究结果强调了理解分娩方式对新生儿眼科预后影响的重要性。由于现有研究的数量有限，因此需要进一步研究来证实这种关联：CRD42023486278。
Effect of mode of delivery on incidence of retinopathy of prematurity: a systematic review and meta-analysis.
Background: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Prompt diagnosis and treatment are crucial in ROP management. Thus, the identification of prominent risk factors could facilitate immediate action. Among various risk factors, the effects of mode of delivery on ROP remain unclear. Therefore, this study aims to assess the association between different modes of delivery on ROP incidence.
Methods and analysis: Comprehensive literature search was conducted on PubMed, ProQuest, EBSCOHost and Cochrane databases, to evaluate the association of mode of delivery-vaginal delivery or caesarean section (c-section)-and the incidence of ROP from inception to December 2023. Random-effects meta-analysis was performed to estimate the pooled OR along with their 95% CIs.
Results: This review included 5 cohort studies involving 2048 babies. A higher incidence of ROP was observed in infants born through vaginal delivery compared with caesarean section. Meta-analysis showed that C-section decreased the unadjusted odds of having ROP infants by 46% with low heterogeneity (OR 0.54 (95% CI 0.40 to 0.73); I2=40.73%). However, pooled adjusted effects were statistically insignificant with moderate heterogeneity (adjusted OR 0.59 (95% CI 0.28 to 1.23); I2=70.51%), possibly stemming from multiple variations in the controlled variables of each study.
Conclusion: Despite varying statistical significance, our findings underscore the crucial need to comprehend the influence of delivery mode on neonatal ophthalmic outcomes. Due to a limited number of existing studies, further research is needed to confirm the association.
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