模仿癌症干细胞，实现免疫逃避和抗药性

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-06-25 DOI:10.1016/j.stem.2024.06.003

Phei Er Saw, Qiang Liu, Ping-Pui Wong, Erwei Song

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引用次数: 0

摘要

癌症干细胞（CSC）是异质性的，具有自我更新属性，并在肿瘤中协调重要的串联。我们提出，癌干细胞状态代表了癌细胞的 "模仿"，从而导致表型可塑性。我们认为，CSC 的 "拟态 "是指 CSC 可以假冒免疫细胞、血管内皮细胞或淋巴管生成细胞来支持癌症的生长。造血干细胞可促进旁分泌和共分泌信号，促使肿瘤相关免疫细胞和基质细胞采用有利于肿瘤的表型，从而产生抗药性。在这里，我们概述了 CSC 在逃避免疫检测过程中的模仿能力，这导致了免疫治疗的抗药性，并重点介绍了针对 CSC 模仿的强效免疫治疗策略。

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Cancer stem cell mimicry for immune evasion and therapeutic resistance

Cancer stem cells (CSCs) are heterogeneous, possess self-renewal attributes, and orchestrate important crosstalk in tumors. We propose that the CSC state represents “mimicry” by cancer cells that leads to phenotypic plasticity. CSC mimicry is suggested as CSCs can impersonate immune cells, vasculo-endothelia, or lymphangiogenic cells to support cancer growth. CSCs facilitate both paracrine and juxtracrine signaling to prime tumor-associated immune and stromal cells to adopt pro-tumoral phenotypes, driving therapeutic resistance. Here, we outline the ingenuity of CSCs’ mimicry in their quest to evade immune detection, which leads to immunotherapeutic resistance, and highlight CSC-mimicry-targeted therapeutic strategies for robust immunotherapy.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.