突变体 Streptomyces avermitilis HU02-06 的两种新型芳香族十维菌素。

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-06-24 DOI:10.1038/s41429-024-00754-y

Hui Zhang, Zhen-yu Wang, Huan Qi, Shao-yong Zhang, Jun Huang, Ji-dong Wang, Wen-sheng Xiang

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引用次数: 0

摘要

从 Streptomyces avermitilis HU02-06 的发酵液中分离出了两种新的芳香族十维菌素（TVMs）：13-oleandrosyl-oleandrosyloxy ST906 (1) 和芳香族 TVM B (2)。通过广泛的光谱分析，包括一维、二维核磁共振和 HRESIMS 数据，确定了它们的结构。生物测定表明，这两种新的十恶霉菌素对嗜木刺吸虫具有微弱的杀线虫活性，对肿瘤细胞株 HepG2 和 HCT116 具有中等程度的细胞毒性活性。

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Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06

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Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06

Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data. Bioassay test showed that these two new tenvermectins exhibited weak nematocidal activity against Bursaphelenchus xylophilus and moderate cytotoxic activity against tumor cell lines HepG2 and HCT116.

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.