{"title":"西阿尔及利亚急性髓性白血病患者FTL3-ITD突变的临床概况。","authors":"Fatima Zohra Moghtit, Wefa Boughrara, Samia Dorgham, Ilies Koriche, Imene Ouahba, Amina Ammour, Amine Bekadja, Meriem Samia Aberkane","doi":"10.22099/mbrc.2024.49437.1955","DOIUrl":null,"url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 ligand gene (<i>FLT3</i>-ITD) represents an important factor in the prognosis of AML. The objective of this study was to determine for the first time the prevalence of <i>FLT3</i>-ITD mutation in west Algerian AML patients. A total of 160 AML patients were genotyped for <i>FLT3</i>-ITD mutation by using polymerase chain reaction. <i>FLT3</i>-ITD mutation was detected in 13% of patients. Mutation rates show no significant difference in the distribution of sex and age. A positive association was found between this mutation and a higher leukocyte and blast cells counts. We also found that the M3 and M5 subtype were the commonest in the <i>FLT3</i> mutated group. This preliminary study provides first-time prevalence estimates for <i>FLT3</i>-ITD mutation in acute myeloid leukemia patients from the West region of Algeria.</p>","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194026/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical profile of <i>FTL3</i>-ITD mutation in West Algerian population with acute myeloid leukemia.\",\"authors\":\"Fatima Zohra Moghtit, Wefa Boughrara, Samia Dorgham, Ilies Koriche, Imene Ouahba, Amina Ammour, Amine Bekadja, Meriem Samia Aberkane\",\"doi\":\"10.22099/mbrc.2024.49437.1955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 ligand gene (<i>FLT3</i>-ITD) represents an important factor in the prognosis of AML. The objective of this study was to determine for the first time the prevalence of <i>FLT3</i>-ITD mutation in west Algerian AML patients. A total of 160 AML patients were genotyped for <i>FLT3</i>-ITD mutation by using polymerase chain reaction. <i>FLT3</i>-ITD mutation was detected in 13% of patients. Mutation rates show no significant difference in the distribution of sex and age. A positive association was found between this mutation and a higher leukocyte and blast cells counts. We also found that the M3 and M5 subtype were the commonest in the <i>FLT3</i> mutated group. This preliminary study provides first-time prevalence estimates for <i>FLT3</i>-ITD mutation in acute myeloid leukemia patients from the West region of Algeria.</p>\",\"PeriodicalId\":19025,\"journal\":{\"name\":\"Molecular Biology Research Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194026/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Biology Research Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22099/mbrc.2024.49437.1955\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biology Research Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22099/mbrc.2024.49437.1955","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia.
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 ligand gene (FLT3-ITD) represents an important factor in the prognosis of AML. The objective of this study was to determine for the first time the prevalence of FLT3-ITD mutation in west Algerian AML patients. A total of 160 AML patients were genotyped for FLT3-ITD mutation by using polymerase chain reaction. FLT3-ITD mutation was detected in 13% of patients. Mutation rates show no significant difference in the distribution of sex and age. A positive association was found between this mutation and a higher leukocyte and blast cells counts. We also found that the M3 and M5 subtype were the commonest in the FLT3 mutated group. This preliminary study provides first-time prevalence estimates for FLT3-ITD mutation in acute myeloid leukemia patients from the West region of Algeria.
期刊介绍：
“Molecular Biology Research Communications” (MBRC) is an international journal of Molecular Biology. It is published quarterly by Shiraz University (Iran). The MBRC is a fully peer-reviewed journal. The journal welcomes submission of Original articles, Short communications, Invited review articles, and Letters to the Editor which meets the general criteria of significance and scientific excellence in all fields of “Molecular Biology”.
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