表观遗传调节剂提供了一条了解疾病和治疗机会的途径。

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2024-07-19 DOI:10.1101/gad.351444.123

Madison A Honer, Benjamin I Ferman, Zach H Gray, Elena A Bondarenko, Johnathan R Whetstine

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引用次数: 0

摘要

表观遗传调节剂（书写者、擦除者、阅读者和重塑者）的发现揭示了以前未被充分认识到的促进疾病发生的生物机制。有了这些洞察力，新的生物标志物和创新的综合疗法就可以用来应对具有挑战性和难以治疗的疾病状态。这篇综述重点介绍了表观遗传撰写者、擦除者、阅读者和重塑者控制的关键机制，以及它们与疾病状态的联系和相关表观遗传疗法的最新进展。

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Epigenetic modulators provide a path to understanding disease and therapeutic opportunity.

The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).