吸烟时间、健康饮食与吸烟者罹患慢性肾脏病的风险:英国生物库的研究结果。

IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY
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引用次数: 0

摘要

理由和目标:虽然吸烟是慢性肾脏病(CKD)的公认风险因素,但每天起床后开始吸烟的时间与CKD之间的关系在很大程度上仍未得到研究。本研究探讨了这一时间与慢性肾脏病风险之间的关系,以及吸烟时间与慢性肾脏病发生的其他风险因素之间的潜在相互作用:观察性队列研究:研究对象:英国生物库中的 32,776 名参与者,这些参与者拥有从起床到吸第一支烟的完整数据,并且没有流行性 CKD:分析方法:分析方法:采用 Cox 比例危险回归法研究每天开始吸烟的时间与 CKD 风险之间的关系。在乘法和加法尺度上评估了吸烟时间与CKD风险之间的潜在相互作用:结果:在中位 12 年的随访期间,共发生了 940 例慢性肾脏病。从起床到吸第一支烟的时间越短,发生慢性肾脏病的风险越高(P-趋势=0.01)。与>120分钟相比,61-120分钟与吸烟时间相关的调整后危险比(HR)为1.28(95% CI:0.92-1.80),30-60分钟为1.48(95% CI:1.11-1.96),5-15分钟为1.36(95% CI:1.01-1.88),5-15分钟为1.70(95% CI:1.22-2.37):可推广性;可能的残余混杂限制了因果推论:这些研究结果表明,从起床到吸第一支烟的时间越短,患慢性肾脏病的风险越高。在饮食不健康的情况下,这种关联的程度更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank

Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank

Rationale & Objective

Although smoking is a recognized risk factor for chronic kidney disease (CKD), the relationship between the time smoking is initiated after awakening each day and CKD remains largely unstudied. This study examined the association between this timing and the risk of CKD, and the potential interactions of smoking timing with other risk factors for the occurrence of CKD.

Study Design

Observational cohort study.

Setting & Participants

A total of 32,776 participants in the UK Biobank with complete data on the time from waking to the first cigarette and free of prevalent CKD were included.

Exposure

Time from waking to the first cigarette.

Outcome

Incident CKD cases.

Analytical Approach

Cox proportional hazards regression was used to investigate the associations between the time smoking is initiated each day and the risk of CKD. The potential interactions of smoking timing with risk factors in relationship to CKD risk were assessed on both multiplicative and additive scales.

Results

During a median follow-up period of 12 years, 940 incident CKD cases occurred. Shorter durations of time from waking to the first cigarette were associated with a higher risk of incident CKD (P trend = 0.01). Compared with >120 minutes, the adjusted hazard ratio (HR) associated with smoking timing was 1.28 (95% CI, 0.92–1.80) for 61-120 minutes, 1.48 (95% CI, 1.11-1.96) for 30-60 minutes, 1.36 (95% CI, 1.01-1.88) for 5-15 minutes, and 1.70 (95% CI, 1.22-2.37) for <5 minutes, respectively. Furthermore, there was a significant additive interaction and multiplicative interactions between the timing of smoking and a healthy diet score (P for additive interaction = 0.01; P for multiplicative interaction = 0.004).

Limitations

Generalizability, possible residual confounding, limiting causal inference.

Conclusions

These findings reveal a significant association between the shorter time from waking to the first cigarette and a higher CKD risk. The magnitude of these associations was greater in the setting of an unhealthy diet.

Plain-Language Summary

This study explored the association of the daily timing of first cigarette smoking and the occurrence of kidney disease. Further, we addressed whether this association was influenced by the quality of the diet. The study found that smoking very soon after waking, especially when combined with a poorer quality diet, was associated with a significantly increased risk of developing chronic kidney disease. This research emphasizes the value of healthier lifestyle choices for kidney health.
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来源期刊
American Journal of Kidney Diseases
American Journal of Kidney Diseases 医学-泌尿学与肾脏学
CiteScore
20.40
自引率
2.30%
发文量
732
审稿时长
3-8 weeks
期刊介绍: The American Journal of Kidney Diseases (AJKD), the National Kidney Foundation's official journal, is globally recognized for its leadership in clinical nephrology content. Monthly, AJKD publishes original investigations on kidney diseases, hypertension, dialysis therapies, and kidney transplantation. Rigorous peer-review, statistical scrutiny, and a structured format characterize the publication process. Each issue includes case reports unveiling new diseases and potential therapeutic strategies.
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