失重会导致生长卵泡中的颗粒细胞增加。

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2024-06-22 DOI:10.1038/s41526-024-00413-4

Anna Yu Kikina, Mariia S Matrosova, Elena Yu Gorbacheva, Ksenia K Gogichaeva, Konstantin A Toniyan, Valery V Boyarintsev, Oleg V Kotov, Irina V Ogneva

{"title":"失重会导致生长卵泡中的颗粒细胞增加。","authors":"Anna Yu Kikina, Mariia S Matrosova, Elena Yu Gorbacheva, Ksenia K Gogichaeva, Konstantin A Toniyan, Valery V Boyarintsev, Oleg V Kotov, Irina V Ogneva","doi":"10.1038/s41526-024-00413-4","DOIUrl":null,"url":null,"abstract":"The participation of women in space programs of increasing flight duration requires research of their reproductive system from the perspective of subsequent childbearing and healthy aging. For the first time, we present hormonal and structural data on the dynamics of recovery after a 157-day space flight in a woman of reproductive age. There were no clinically significant changes in the reproductive system, but detailed analysis shows that weightlessness leads to an increase in the proportion of early antral follicles and granulosa cells in large antral follicles. Returning to Earth's gravity reduces the number and diameter of early antral follicles.","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"10 1","pages":"70"},"PeriodicalIF":4.4000,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193763/pdf/","citationCount":"0","resultStr":"{\"title\":\"Weightlessness leads to an increase granulosa cells in the growing follicle.\",\"authors\":\"Anna Yu Kikina, Mariia S Matrosova, Elena Yu Gorbacheva, Ksenia K Gogichaeva, Konstantin A Toniyan, Valery V Boyarintsev, Oleg V Kotov, Irina V Ogneva\",\"doi\":\"10.1038/s41526-024-00413-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The participation of women in space programs of increasing flight duration requires research of their reproductive system from the perspective of subsequent childbearing and healthy aging. For the first time, we present hormonal and structural data on the dynamics of recovery after a 157-day space flight in a woman of reproductive age. There were no clinically significant changes in the reproductive system, but detailed analysis shows that weightlessness leads to an increase in the proportion of early antral follicles and granulosa cells in large antral follicles. Returning to Earth's gravity reduces the number and diameter of early antral follicles.\",\"PeriodicalId\":54263,\"journal\":{\"name\":\"npj Microgravity\",\"volume\":\"10 1\",\"pages\":\"70\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193763/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj Microgravity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41526-024-00413-4\",\"RegionNum\":1,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Microgravity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41526-024-00413-4","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

女性参与飞行时间越来越长的太空项目，需要从以后生育和健康老龄化的角度对她们的生殖系统进行研究。我们首次提供了育龄女性在 157 天太空飞行后的荷尔蒙和结构恢复动态数据。生殖系统在临床上没有明显变化，但详细分析显示，失重会导致早期前列腺卵泡和大前列腺卵泡中颗粒细胞的比例增加。回到地球重力环境后，早期前列腺卵泡的数量和直径都会减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Weightlessness leads to an increase granulosa cells in the growing follicle.

The participation of women in space programs of increasing flight duration requires research of their reproductive system from the perspective of subsequent childbearing and healthy aging. For the first time, we present hormonal and structural data on the dynamics of recovery after a 157-day space flight in a woman of reproductive age. There were no clinically significant changes in the reproductive system, but detailed analysis shows that weightlessness leads to an increase in the proportion of early antral follicles and granulosa cells in large antral follicles. Returning to Earth's gravity reduces the number and diameter of early antral follicles.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.