运动可减少胎儿酒精中毒谱系障碍大鼠模型的身体改变。

IF 4.3 2区 生物学 Q1 BIOLOGY
Ronald Vargas-Foitzick, Bayron García-Ordenes, Donovan Iratchet, Angie Acuña, Spencer Alcayaga, Cristian Fernández, Karla Toledo, Marianela Rodríguez, Carolina Naranjo, René Bustamante, Paola A Haeger
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引用次数: 0

摘要

背景:产前酒精暴露(PAE)会对儿童的身体造成严重后果,如行为障碍、生长障碍、神经肌肉问题、运动协调能力受损和肌肉张力下降。然而,目前尚不清楚肌肉力量是否会丧失,也不知道哪些干预措施能有效减轻 PAE 对身体造成的损害。我们的目的是调查体能改变是否会在青春期持续存在,以及运动是否是一种有效的干预措施:结果:通过使用范式评估不同的身体素质,我们发现青春期早期 PAE 动物与 CTRL 动物相比,在灵活性和力量方面有显著改变,而在平衡和协调方面没有改变。我们评估了 3 种不同运动方案的效果,为期 4 周:充实环境(EE)、耐力锻炼(EEX)和阻力锻炼(REX)。充实环境明显改善了 PAE 组的力量,但 CTRL 组的力量参数在运动过程中仍能保持不变。阻力运动对增强力量的益处最大,而耐力运动则不然:结论:与 CTRL 相比,PAE 会导致 PND21 的力量显著下降。阻力运动对逆转 PAE 对肌肉力量的影响最为有效。我们的数据表明,对 FASD 青少年而言,个性化、有计划和有监督的阻力训练比耐力锻炼或丰富环境锻炼更有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise reduces physical alterations in a rat model of fetal alcohol spectrum disorders.

Background: Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth disorders, neuromuscular problems, impaired motor coordination, and decreased muscle tone. However, it is not known whether loss of muscle strength occurs, and which interventions will effectively mitigate physical PAE impairments. We aimed to investigate whether physical alteration persists during adolescence and whether exercise is an effective intervention.

Results: Using paradigms to evaluate different physical qualities, we described that early adolescent PAE animals have significant alterations in agility and strength, without alterations in balance and coordination compared to CTRL animals. We evaluated the effectiveness of 3 different exercise protocols for 4 weeks: Enrichment environment (EE), Endurance exercise (EEX), and Resistance exercise (REX). The enriched environment significantly improved the strength in the PAE group but not in the CTRL group whose strength parameters were maintained even during exercise. Resistance exercise showed the greatest benefits in gaining strength, and endurance exercise did not.

Conclusion: PAE induced a significant decrease in strength compared to CTRL in PND21. Resistance exercise is the most effective to reverse the effects of PAE on muscular strength. Our data suggests that individualized, scheduled, and supervised training of resistance is more beneficial than endurance or enriched environment exercise for adolescents FASD.

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来源期刊
Biological Research
Biological Research 生物-生物学
CiteScore
10.10
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: Biological Research is an open access, peer-reviewed journal that encompasses diverse fields of experimental biology, such as biochemistry, bioinformatics, biotechnology, cell biology, cancer, chemical biology, developmental biology, evolutionary biology, genetics, genomics, immunology, marine biology, microbiology, molecular biology, neuroscience, plant biology, physiology, stem cell research, structural biology and systems biology.
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