Samuel R Schnittman, Ria Talathi, Moses Q Wilks, Sandeep Hedgire, Michael T Lu, Lindsay T Fourman, David A Alagpulinsa, Sara L Stockman, Kevin S White, Zoey K Wallis, Patrick Autissier, Takara L Stanley, Hang Lee, Michael C Honigberg, Georges El-Fakhri, Kenneth C Williams, Markella V Zanni, Steven K Grinspoon, Mabel Toribio
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引用次数: 0
摘要
与普通人群相比，人类免疫缺陷病毒（HIV，PWH）感染者罹患心血管疾病（CVD）的风险更高。我们以前曾证实，与全身单核细胞活化有关，艾滋病病毒感染者（与非艾滋病病毒感染者相比）具有更高的巨噬细胞特异性动脉浸润。我们现在的研究表明，在感染艾滋病毒和未感染艾滋病毒的参与者中，特定的 T 淋巴细胞亚群（幼稚 CD4+、效应记忆 CD4+ 和中枢记忆 CD8+）与巨噬细胞特异性动脉浸润有不同的关联，并有证据表明艾滋病毒感染状况与巨噬细胞特异性动脉浸润存在相互作用。我们的研究结果表明，在PWH人群中，循环T淋巴细胞与巨噬细胞特异性动脉浸润相关，与动脉粥样硬化和心血管疾病风险有关：临床试验注册：NCT02542371。
Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV.
People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4 + , effector memory CD4 + , and central memory CD8 + ) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk.
期刊介绍：
Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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