Rahime Aksoy , Tahsin Murat Turgay , Recep Yilmaz , Serdar Sezer , Müçteba Enes Yayla , Emine Uslu Yurteri
{"title":"高安症和巨细胞动脉炎患者的血清白血病抑制因子 (LIF) 水平：横断面研究","authors":"Rahime Aksoy , Tahsin Murat Turgay , Recep Yilmaz , Serdar Sezer , Müçteba Enes Yayla , Emine Uslu Yurteri","doi":"10.1016/j.reuma.2024.02.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>In this study, we aimed to evaluate LIF levels and its possible relationship with disease activity in patients with Takayasu's (TAK) and Giant cell arteritis (GCA) patients.</p></div><div><h3>Materials and methods</h3><p>23 Takayasu's arteritis, 9 Giant cell arteritis patients and 25 healthy volunteers were included in the study. Serum LIF levels were measured ELISA.</p></div><div><h3>Results</h3><p>The mean age of Giant cell arteritis patients was statistically significantly higher than the other groups (<em>p</em> <!--><<!--> <!-->0.001). The rate of women was found to be higher in Takayasu's arteritis (<em>p</em> <!-->=<!--> <!-->0.021). When healthy control, patients with GCA and Takayasu arteritis were compared, there was a difference in LIF values (<em>p</em> <!-->=<!--> <!-->0.018). In subgroup analyzes, LIF values were found to be higher in GCA patients compared to healthy controls (<em>p</em> <!--><<!--> <!-->0.05). There was no statistically significant correlation between LIF and CRP (Rho<!--> <!-->=<!--> <!-->−0.038, <em>p</em> <!-->=<!--> <!-->0.778), ESR (Rho<!--> <!-->=<!--> <!-->0.114, <em>p</em> <!-->=<!--> <!-->0.399) and ITAS (Rho<!--> <!-->=<!--> <!-->−0.357, <em>p</em> <!-->=<!--> <!-->0.094). While CRP was statistically significantly higher in patients with disease activity (<em>p</em> <!-->=<!--> <!-->0.003), there was no statistically significant difference between patients in terms of ESR and LIF values. While there was a statistically significant relationship between CRP (OR<!--> <!-->=<!--> <!-->1.19 [1.03–1.37], <em>p</em> <!-->=<!--> <!-->0.018) and disease activity in univariate analyses, no statistically significant variable was found in multivariable analyses.</p></div><div><h3>Conclusions</h3><p>LIF values were significantly higher in patients with Giant cell arteritis compared to healthy controls.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum leukemia inhibitory factor (LIF) levels in patients with Takayasu's and Giant cell arteritis: A cross-sectional study\",\"authors\":\"Rahime Aksoy , Tahsin Murat Turgay , Recep Yilmaz , Serdar Sezer , Müçteba Enes Yayla , Emine Uslu Yurteri\",\"doi\":\"10.1016/j.reuma.2024.02.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction and objectives</h3><p>In this study, we aimed to evaluate LIF levels and its possible relationship with disease activity in patients with Takayasu's (TAK) and Giant cell arteritis (GCA) patients.</p></div><div><h3>Materials and methods</h3><p>23 Takayasu's arteritis, 9 Giant cell arteritis patients and 25 healthy volunteers were included in the study. Serum LIF levels were measured ELISA.</p></div><div><h3>Results</h3><p>The mean age of Giant cell arteritis patients was statistically significantly higher than the other groups (<em>p</em> <!--><<!--> <!-->0.001). The rate of women was found to be higher in Takayasu's arteritis (<em>p</em> <!-->=<!--> <!-->0.021). When healthy control, patients with GCA and Takayasu arteritis were compared, there was a difference in LIF values (<em>p</em> <!-->=<!--> <!-->0.018). In subgroup analyzes, LIF values were found to be higher in GCA patients compared to healthy controls (<em>p</em> <!--><<!--> <!-->0.05). There was no statistically significant correlation between LIF and CRP (Rho<!--> <!-->=<!--> <!-->−0.038, <em>p</em> <!-->=<!--> <!-->0.778), ESR (Rho<!--> <!-->=<!--> <!-->0.114, <em>p</em> <!-->=<!--> <!-->0.399) and ITAS (Rho<!--> <!-->=<!--> <!-->−0.357, <em>p</em> <!-->=<!--> <!-->0.094). While CRP was statistically significantly higher in patients with disease activity (<em>p</em> <!-->=<!--> <!-->0.003), there was no statistically significant difference between patients in terms of ESR and LIF values. While there was a statistically significant relationship between CRP (OR<!--> <!-->=<!--> <!-->1.19 [1.03–1.37], <em>p</em> <!-->=<!--> <!-->0.018) and disease activity in univariate analyses, no statistically significant variable was found in multivariable analyses.</p></div><div><h3>Conclusions</h3><p>LIF values were significantly higher in patients with Giant cell arteritis compared to healthy controls.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1699258X24000184\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1699258X24000184","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Serum leukemia inhibitory factor (LIF) levels in patients with Takayasu's and Giant cell arteritis: A cross-sectional study
Introduction and objectives
In this study, we aimed to evaluate LIF levels and its possible relationship with disease activity in patients with Takayasu's (TAK) and Giant cell arteritis (GCA) patients.
Materials and methods
23 Takayasu's arteritis, 9 Giant cell arteritis patients and 25 healthy volunteers were included in the study. Serum LIF levels were measured ELISA.
Results
The mean age of Giant cell arteritis patients was statistically significantly higher than the other groups (p < 0.001). The rate of women was found to be higher in Takayasu's arteritis (p = 0.021). When healthy control, patients with GCA and Takayasu arteritis were compared, there was a difference in LIF values (p = 0.018). In subgroup analyzes, LIF values were found to be higher in GCA patients compared to healthy controls (p < 0.05). There was no statistically significant correlation between LIF and CRP (Rho = −0.038, p = 0.778), ESR (Rho = 0.114, p = 0.399) and ITAS (Rho = −0.357, p = 0.094). While CRP was statistically significantly higher in patients with disease activity (p = 0.003), there was no statistically significant difference between patients in terms of ESR and LIF values. While there was a statistically significant relationship between CRP (OR = 1.19 [1.03–1.37], p = 0.018) and disease activity in univariate analyses, no statistically significant variable was found in multivariable analyses.
Conclusions
LIF values were significantly higher in patients with Giant cell arteritis compared to healthy controls.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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