II 型糖尿病患者亚临床甲状腺机能减退对生化、凝血和纤维蛋白溶解状态的影响。

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2024-04-01 Epub Date: 2024-05-06 DOI:10.4103/JAPTR.JAPTR_89_24

Yasir Abbas Atia, Suhad Taha Mohammed, Sarmad S Abdullah, Ahmed Saad Abbas, Hayder Adnan Fawzi

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引用次数: 0

摘要

本研究旨在探讨糖尿病患者亚临床甲状腺功能减退症（SCH）对凝血参数的影响。这项回顾性病例对照研究涉及 130 名确诊为 2 型糖尿病（T2DM）的患者，分为 65 名新确诊患有亚临床甲状腺功能减退症（SCH）的 T2DM 患者和 65 名未患有亚临床甲状腺功能减退症（SCH）的甲状腺功能正常（EUT）T2DM 患者。SCH患者的纤维蛋白原（FIB）（508.2 ± 63.0 mg/dL）明显高于EUT患者（428.1 ± 44.8 mg/dL）。在 SCH 患者中，FIB 与多个参数相关，如年龄（β = 0.396）、体重指数（β = 0.578）、糖化血红蛋白（β = 0.281）和活化部分凝血活酶时间（β = 0.276）。总之，DM 患者的 SCH 似乎会增加凝血病的程度。

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Effects of subclinical hypothyroidism in type II diabetes mellitus patients on biochemical, coagulation, and fibrinolysis status.

The aim of the currnet study to examine the effect of subclinical hypothyroidism (SCH) in diabetic patients on coagulation parameters. This retrospective case-control study involves 130 patients diagnosed with type 2 diabetes mellitus (T2DM), divided into 65 T2DM with newly diagnosed SCH and 65 euthyroid (EUT) T2DM patients without SCH. Fibrinogen (FIB) was significantly higher in SCH (508.2 ± 63.0 mg/dL) than EUT (428.1 ± 44.8 mg/dL). In the SCH patients, FIB correlated with several parameters, such as age (β = 0.396), body mass index (β = 0.578), glycated hemoglobin (β = 0.281), and activated partial thromboplastin time (β = 0.276). In conclusion SCH in DM patients appears to increase the magnitude of coagulopathy.

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来源期刊

Journal of Advanced Pharmaceutical Technology & Research PHARMACOLOGY & PHARMACY-

CiteScore

2.00

自引率

7.10%

发文量

审稿时长

20 weeks

期刊介绍： Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.