钴胺素在多发性硬化症中的作用：最新进展。

IF 4.5 2区医学 Q2 CELL BIOLOGY

Inflammation Pub Date : 2024-06-21 DOI:10.1007/s10753-024-02075-6

Marjan Golabi, Danial Kazemi, Amir Shayan Chadeganipour, Hamed Fouladseresht, Mark J M Sullman, Behrooz Ghezelbash, Ava Yeganegi Dastgerdi, Nahid Eskandari

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引用次数: 0

摘要

多发性硬化症（MS）是一种神经退行性疾病，会对中枢神经系统造成轴索和永久性损伤，由于自身免疫反应和持续的神经炎症，必须进行治疗。抗氧化剂和抗炎药物对控制氧化应激和神经炎症至关重要。此外，补充多种维生素，尤其是维生素 B12（钴胺素），可能有利于保护神经元。虽然维生素 B12 缺乏与多发性硬化症之间没有文献记载的联系，但研究人员已探索了其作为代谢原因的可能性。本综述强调了钴胺素（Cbl）对多发性硬化症患者的治疗益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Role of Cobalamin in Multiple Sclerosis: An Update.

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The Role of Cobalamin in Multiple Sclerosis: An Update.

Multiple sclerosis (MS) is a neurodegenerative condition that results in axonal and permanent damage to the central nervous system, necessitating healing owing to autoimmune reactions and persistent neuroinflammation. Antioxidant and anti-inflammatory drugs are essential for the management of oxidative stress and neuroinflammation. Additionally, multivitamin supplementation, particularly vitamin B12 (cobalamin), may be beneficial for neuronal protection. Although there is no documented connection between vitamin B12 deficiency and MS, researchers have explored its potential as a metabolic cause. This review highlights the therapeutic benefits of cobalamin (Cbl) in patients with MS.

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来源期刊

Inflammation 医学-免疫学

CiteScore

9.70

自引率

0.00%

发文量

168

审稿时长

3.0 months

期刊介绍： Inflammation publishes the latest international advances in experimental and clinical research on the physiology, biochemistry, cell biology, and pharmacology of inflammation. Contributions include full-length scientific reports, short definitive articles, and papers from meetings and symposia proceedings. The journal''s coverage includes acute and chronic inflammation; mediators of inflammation; mechanisms of tissue injury and cytotoxicity; pharmacology of inflammation; and clinical studies of inflammation and its modification.