Veronika Prenner, Gregor Sebastian Reiter, Philipp Fuchs, Klaudia Birner, Sophie Frank, Leonard Coulibaly, Markus Gumpinger, Hrvoje Bogunovic, Ursula Schmidt-Erfurth
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Eyes with nAMD and at least 250 nL of retinal fluid, quantified by an approved deep-learning algorithm (Fluid Monitor, RetInSight, Vienna, Austria), fulfilled the inclusion criteria. The outer retinal layers were segmented using automated layer segmentation and were corrected manually. Layer loss and thickness were compared between both devices using a linear mixed-effects model and a paired t test.</p><p><strong>Results: </strong>Nineteen eyes of 17 patients with active nAMD and 17 healthy eyes were included. For nAMD eyes, the thickness of the retinal pigment epithelium (RPE) differed significantly between the devices (25.42 μm [95% CI, 14.24-36.61] and 27.31 μm [95% CI, 16.12-38.50] for high-resolution OCT and conventional OCT, respectively; p = 0.033). Furthermore, a significant difference was found in the mean relative external limiting membrane loss (p = 0.021). 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引用次数: 0
摘要
目的比较两种 OCT 设备在新生血管性老年黄斑变性(nAMD)患者视网膜外层的可见性和可及性:在这项前瞻性、横断面探索性研究中,我们分析了下一代高分辨率 OCT 设备和传统 SPECTRALIS OCT(均为德国海德堡海德堡工程有限公司生产)在新生血管性老年性黄斑变性患者和年龄匹配的健康眼中视网膜外层厚度和各层损失的差异。经认可的深度学习算法(Fluid Monitor, RetInSight, Vienna, Austria)量化的 nAMD 眼球和至少 250 nL 的视网膜积液符合纳入标准。视网膜外层采用自动视网膜层分割法进行分割,并进行人工校正。使用线性混合效应模型和配对 t 检验比较两种设备的视网膜层损失和厚度:共纳入了 17 名活动性 nAMD 患者和 17 名健康患者的 19 只眼睛。对于 nAMD 眼睛,两种设备的视网膜色素上皮(RPE)厚度差异显著(高分辨率 OCT 和传统 OCT 分别为 25.42 μm [95% CI,14.24-36.61] 和 27.31 μm [95% CI,16.12-38.50];P = 0.033)。此外,平均相对外缘膜损耗也存在明显差异(p = 0.021)。然而,在中央 3 毫米的范围内,不同设备的感光体厚度、RPE 完整性损失和感光体完整性损失没有显著差异。在健康眼睛中,不同设备的 RPE 和光感受器厚度均有显著差异(p < 0.001):结论:与传统 OCT 图像相比,高分辨率 OCT 图像的中央 RPE 厚度明显较薄,这是因为 RPE 和布鲁氏膜的光学分离度较高。
Advancing the visibility of outer retinal integrity in neovascular age-related macular degeneration with high-resolution OCT.
Objective: To compare the visibility and accessibility of the outer retina in neovascular age-related macular degeneration (nAMD) between 2 OCT devices.
Methods: In this prospective, cross-sectional exploratory study, differences in thickness and loss of individual outer retinal layers in eyes with nAMD and in age-matched healthy eyes between a next-level High-Res OCT device and the conventional SPECTRALIS OCT (both Heidelberg Engineering GmbH, Heidelberg, Germany) were analyzed. Eyes with nAMD and at least 250 nL of retinal fluid, quantified by an approved deep-learning algorithm (Fluid Monitor, RetInSight, Vienna, Austria), fulfilled the inclusion criteria. The outer retinal layers were segmented using automated layer segmentation and were corrected manually. Layer loss and thickness were compared between both devices using a linear mixed-effects model and a paired t test.
Results: Nineteen eyes of 17 patients with active nAMD and 17 healthy eyes were included. For nAMD eyes, the thickness of the retinal pigment epithelium (RPE) differed significantly between the devices (25.42 μm [95% CI, 14.24-36.61] and 27.31 μm [95% CI, 16.12-38.50] for high-resolution OCT and conventional OCT, respectively; p = 0.033). Furthermore, a significant difference was found in the mean relative external limiting membrane loss (p = 0.021). However, the thickness of photoreceptors, RPE integrity loss, and photoreceptor integrity loss did not differ significantly between devices in the central 3 mm. In healthy eyes, a significant difference in both RPE and photoreceptor thickness between devices was shown (p < 0.001).
Conclusion: Central RPE thickness was significantly thinner on high-resolution OCT compared with conventional OCT images explained by superior optical separation of the RPE and Bruch's membrane.
期刊介绍:
Official journal of the Canadian Ophthalmological Society.
The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.