日本 1 型糖尿病成人患者从 MiniMedTM 640G 到 770G 的过渡改善血糖控制:一项前瞻性、单中心、观察性研究。

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-10-01 Epub Date: 2024-06-20 DOI:10.1507/endocrj.EJ24-0136
Satoshi Kubota, Ai Sato, Manami Hosokawa, Yosuke Okubo, Shohei Takayama, Atsuko Kaneko, Yasuho Shimada, Yuki Asano, Yoshihiko Sato, Masanori Yamazaki, Mitsuhisa Komatsu
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引用次数: 0

摘要

混合闭环(HCL)系统在改善日本人血糖控制方面的效果尚不明确。因此,我们评估了 MiniMed 770G HCL 系统对该人群血糖控制的影响。这项前瞻性、单中心、为期 24 周的观察性研究(注册号:UMIN000047394)招募了 23 名使用美敦力 MiniMed 640G 系统的 1 型糖尿病患者。主要终点是转用 MiniMed 770G HCL 系统后,血糖在 70-180 mg/dL 范围内的时间的改善情况。我们观察到,血糖在 70-180 mg/dL 范围内的时间增加了(从 64.1 [55.8-69.5]% 增加到 70.9 [67.1-74.4]%,四分位距为 25-75%,p < 0.001),糖化血红蛋白水平降低了(从 7.4 [7.0-7.9]% 降低到 7.1 [6.8-7.4]%,p = 0.003)。糖化血红蛋白水平超出范围的时间明显减少(181-250 mg/dL: 25.8 [20.9-28.6]% 降至 19.5 [17.1-22.1]%,p < 0.001;>251 mg/dL: 8.7 [4.0-13.0]% 降至 4.7 [3.6-9.1]%,p < 0.001)。低于范围的时间保持不变(54-69 毫克/分升:1.8 [0.4-2.4] 到 2.1 [0.4-3.9] %,p = 0.24;
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improving glycemic control by transitioning from the MiniMedTM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study.

The effectiveness of a hybrid closed-loop (HCL) system in improving glycemic control is unclear in Japanese individuals. Therefore, we assessed the effect impact of the MiniMed 770G HCL system on glycemic control in this population. This prospective, single-center, 24-week observational study (registration number: UMIN000047394) enrolled 23 individuals with type 1 diabetes mellitus using the Medtronic MiniMed 640G system. The primary endpoint was the improvement in time in the range of 70-180 mg/dL after transitioning to the MiniMed 770G HCL system. We observed an increase in time in range (from 64.1 [55.8-69.5] to 70.9 [67.1-74.4] %, interquartile range 25-75%, p < 0.001) and a decrease in glycated hemoglobin level (from 7.4 [7.0-7.9] to 7.1 [6.8-7.4] %, p = 0.003). There was a significant reduction in time above the range (181-250 mg/dL: 25.8 [20.9-28.6] to 19.5 [17.1-22.1] %, p < 0.001; >251 mg/dL: 8.7 [4.0-13.0] to 4.7 [3.6-9.1] %, p < 0.001). Time below the range remained unchanged (54-69 mg/dL: 1.8 [0.4-2.4] to 2.1 [0.4-3.9] %, p = 0.24; <54 mg/dL: 0.2 [0.0-1.0] to 0.5 [0.1-1.3] %, p = 0.14). In a subgroup of 12 patients with a high HCL implementation rate, the basal insulin infusion decreased immediately after mealtime insulin administration and increased after approximately 120 minutes. The ratings from questionnaires assessing treatment burden, satisfaction, and quality of life remained unchanged. The MiniMed 770G HCL system improved glycemic control and optimized insulin delivery, particularly in patients with high implementation rates.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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