由卡波济肉瘤疱疹病毒和 Epstein-Barr 病毒引起的艾滋病毒相关癌症和淋巴增生性疾病。

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2024-09-12 Epub Date: 2024-06-20 DOI:10.1128/cmr.00022-23
Kathryn A Lurain, Ramya Ramaswami, Laurie T Krug, Denise Whitby, Joseph M Ziegelbauer, Hao-Wei Wang, Robert Yarchoan
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引用次数: 0

摘要

摘要在 1981 年首次报告获得性免疫缺陷综合症(艾滋病)后的几周内,人们发现这些患者通常患有卡波西肉瘤(KS),这是一种迄今为止在美国很少见的皮肤肿瘤。很快,人们发现艾滋病还与 Epstein-Barr 病毒(EBV)引起的高级别淋巴瘤发病率增加有关。十多年来,艾滋病与 KS 的关系一直是个谜,直到卡波西肉瘤相关疱疹病毒(KSHV)被发现并被认为是 KS 的病因。随后又发现 KSHV 可导致其他几种与艾滋病和人类免疫缺陷病毒(HIV)感染相关的疾病。艾滋病病毒感染者/艾滋病患者某些癌症的发病率持续上升,其中许多癌症是由 EBV 和/或 KSHV 引起的。在这篇综述中,我们将讨论 HIV 感染者中由 EBV 和 KSHV 引起的癌症的流行病学、病毒学、发病机制、临床表现和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HIV-associated cancers and lymphoproliferative disorders caused by Kaposi sarcoma herpesvirus and Epstein-Barr virus.

SUMMARYWithin weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin tumor in the USA. It soon became apparent that AIDS was also associated with an increased incidence of high-grade lymphomas caused by Epstein-Barr virus (EBV). The association of AIDS with KS remained a mystery for more than a decade until Kaposi sarcoma-associated herpesvirus (KSHV) was discovered and found to be the cause of KS. KSHV was subsequently found to cause several other diseases associated with AIDS and human immunodeficiency virus (HIV) infection. People living with HIV/AIDS continue to have an increased incidence of certain cancers, and many of these cancers are caused by EBV and/or KSHV. In this review, we discuss the epidemiology, virology, pathogenesis, clinical manifestations, and treatment of cancers caused by EBV and KSHV in persons living with HIV.

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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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