革新肾脏研究：生物技术中芯片肾的未来

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2024-06-01 DOI:10.1016/j.reth.2024.06.006

Yusuke Nishimura

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引用次数: 0

摘要

与其他器官相比，肾脏的结构和功能十分复杂，因此肾脏的体外模型效果有限。因此，目前许多肾功能评估都是通过动物实验进行的。相比之下，人们正在努力应用生物仿真系统，如基于微流控装置技术的芯片器官，作为肾脏的体外模型。这些系统旨在重现生理培养环境。本综述概述了以肾小球和肾小管为肾脏体外模型的片上器官研究，并讨论了未来的前景。

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Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology

In vitro models of kidneys have limited effectiveness owing to the complex structure and functions of the kidney when compared with other organs. Therefore many renal function evaluations are currently being carried out through animal experiments. In contrast, efforts are being made to apply biomimetic systems, such as organ-on-a-chip, which is based on microfluidic device technology, to serve as an in vitro model for the kidney. These systems aimed to recreate a physiological cultivation environment. This review has provided an overview of organ-on-a-chip research focused on glomeruli and tubules as in vitro models for the kidney and discusses future prospects.

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.