甲烷营养菌和其他甲基营养菌的工业化:从生物工程到产品回收

IF 7.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Dominic Sauvageau , Lisa Y Stein , Elizabeth Arenas , Shibashis Das , Maryssa Iacobelli , Mark Lawley , Marina Lazic , Fabián L Rondón , Cerrise Weiblen
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引用次数: 0

摘要

利用单碳底物甲醇和甲烷的微生物为生物产业带来了巨大的前景和巨大的环境效益。可以对养甲烷微生物和其他养甲烷微生物进行改造和优化,以生产从生物聚合物到生物燃料等多种产品。虽然仍存在一些重大限制,包括将单碳原料输送到生物反应器、高效生长和扩大规模,但这些挑战正在得到解决,并已迅速取得显著进展。表达底盘的开发、基因组尺度和基于组学数据的调控模型的使用、生物反应器设计和操作的改进以及绿色产品回收方案的开发,都使单碳生物转化在工业领域得到了快速发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Industrializing methanotrophs and other methylotrophic bacteria: from bioengineering to product recovery

Microbes that use the single-carbon substrates methanol and methane offer great promise to bioindustry along with substantial environmental benefits. Methanotrophs and other methylotrophs can be engineered and optimized to produce a wide range of products, from biopolymers to biofuels and beyond. While significant limitations remain, including delivery of single-carbon feedstock to bioreactors, efficient growth, and scale-up, these challenges are being addressed and notable improvements have been rapid. Development of expression chassis, use of genome-scale and regulatory models based on omics data, improvements in bioreactor design and operation, and development of green product recovery schemes are enabling the rapid development of single-carbon bioconversion in the industrial space.

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来源期刊
Current opinion in biotechnology
Current opinion in biotechnology 工程技术-生化研究方法
CiteScore
16.20
自引率
2.60%
发文量
226
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.
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