重命名，不驯服：血管免疫母细胞 T 细胞淋巴瘤，诊断上的麻烦制造者

Diagnostic Histopathology Pub Date : 2024-08-01 DOI:10.1016/j.mpdhp.2024.05.007

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引用次数: 0

摘要

血管免疫母细胞性T细胞淋巴瘤在第五版《世界卫生组织血液淋巴瘤分类》中被重新归类为结节性T滤泡辅助细胞淋巴瘤（nTFHL-AI）的一种亚型。最近发现结节性T滤泡辅助细胞淋巴瘤（nTFHL-AI）与T滤泡辅助细胞淋巴瘤（TFH）同源，因此将其与相关实体归为一类。大量研究证明，该病有许多奇特的表现，妨碍了对该病的识别。通常需要进行手术活检才能确诊，但手术活检很少作为一线干预措施。延误或漏诊的代价很高。疾病晚期很常见，复发率也很高。尽早发现并改善预后的需求尚未得到满足。在这里，我们介绍了一个显示出 nTFHL-AI 一些典型临床病理特征的病例，并讨论了辨别这些特征的方法。

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Renamed, not tamed: angioimmunoblastic T-cell lymphoma, a diagnostic troublemaker

Angioimmunoblastic T-cell lymphoma was reclassified a subtype of nodal T-follicular helper cell lymphoma (nTFHL-AI) in the 5^th Edition of the World Health Organization Classification of Haematolymphoid Tumours. It is now grouped with related entities upon recent discovery of a shared T-follicular helper (TFH) cell origin. Numerous studies attest to the many peculiar presentations that impede recognition of the disease. Surgical biopsy is often required to secure a diagnosis though is rarely the first-line intervention. Delayed or missed diagnosis has a high price. Advanced stage of disease at presentation is common and rates of relapse are high. There is an unmet need for earlier detection and improved outcomes. Here we present a case which showed some quintessential clinicopathologic features of nTFHL-AI, and an approach to discerning these is discussed.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.