量化内源性卵巢激素情感敏感性的新方法

IF 3.4 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Elizabeth H. Andersen , Anisha Nagpal , Tory A. Eisenlohr-Moul , Jennifer L. Gordon
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引用次数: 0

摘要

对卵巢激素变化的敏感性增加与女性一生中生殖情绪障碍的病因有关,包括与月经有关的情绪障碍、围产期情绪障碍和围绝经期抑郁症。因此,开发一种方法来准确量化对内源性激素波动的敏感性,可能有助于预测和预防这些心理健康问题。在这里,我们提出了一种这样的方法,即应用同步分析来计算重复评估的内源性激素水平与自我报告的情绪之间的时滞交叉相关性。我们将这种方法应用于一个数据集,该数据集包含对 94 名围绝经期女性的情感症状以及雌二醇(E2)和孕酮(P4)尿液代谢物的频繁重复评估。这些初步研究结果表明,经过进一步完善和验证,所提出的方法有望成为一种诊断工具,用于临床实践,并推动对生殖情绪障碍病因的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel method for quantifying affective sensitivity to endogenous ovarian hormones

Increased sensitivity to ovarian hormone changes is implicated in the etiology of reproductive mood disorders across the female lifespan, including menstrually-related mood disorders, perinatal mood disorders, and perimenopausal depression. Developing a method to accurately quantify sensitivity to endogenous hormone fluctuations may therefore facilitate the prediction and prevention of these mental health conditions. Here, we propose one such method applying a synchrony analysis to compute time-lagged cross-correlations between repeated assessments of endogenous hormone levels and self-reported affect. We apply this method to a dataset containing frequent repeated assessments of affective symptoms and the urinary metabolites of estradiol (E2) and progesterone (P4) in 94 perimenopausal females. These preliminary findings suggest that, with further refinement and validation, the proposed method holds promise as a diagnostic tool to be used in clinical practice and to advance research investigating the etiology of reproductive mood disorders.

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来源期刊
Psychoneuroendocrinology
Psychoneuroendocrinology 医学-精神病学
CiteScore
7.40
自引率
8.10%
发文量
268
审稿时长
66 days
期刊介绍: Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.
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