线粒体 18 kDa 转运蛋白是辐射诱发神经炎的生物标志物

Q4 Medicine

Medical Radiology and Radiation Safety Pub Date : 2024-06-01 DOI:10.33266/1024-6177-2024-69-3-35-45

A.V. Rodina

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引用次数: 0

摘要

这篇综述介绍了有关 18 kDa 转运蛋白 TSPO 的结构、其多态变体、其基因表达调控以及在中枢神经系统细胞中的功能的最新知识。文章特别关注其在电离辐射照射后长期神经炎症状态下对小胶质细胞线粒体稳态的作用。本文总结了几种 TSPO 配体在诊断成像和治疗神经炎症以恢复神经退行性病变认知功能方面的有效性数据。根据辐照后晚期大脑和外周血细胞中的 TSPO 水平，讨论了 TSPO 作为神经炎症发展的潜在标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Mitochondrial 18 kDa Translocator Protein as a Biomarker of Radiation-Induced Neuroinflammatory

The review presents current knowledge about the structure of the18 kDa translocator protein TSPO, its polymorphic variants, regulation of its gene expression and function in the cells of CNS. Particular attention is paid to its role in mitochondrial homeostasis in microglia under neuroinflammation in the long-term period after ionizing radiation exposure. Data on the effectiveness of several TSPO ligands for diagnostic imaging and treatment of neuroinflammation for restoring cognitive functions in neurodegenerative pathologies are summarized. Based on the TSPO level in the brain and in the peripheral blood cells late after irradiation, TSPO is discussed as a potential marker of neuroinflammation development.

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来源期刊

Medical Radiology and Radiation Safety Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.40

自引率

0.00%

发文量