眼底皮肤使用 250 μm 与 350 μm 长微针贴片的疗效和安全性比较

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Apisama Arepagorn, J. Meephansan, Punyaphat Sirithanabadeekul, Kittipong Tantisantisom, Sattra Thongma, Y. Rayanasukha, T. Boonkoom, P. Khanchaitit
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Each participant was treated with two different MNP designs, one on each side of the face. The microneedle lengths were 250 μm with a density of 945 needles/cm2 on the left side of the face under the eye and 350 μm with a density of 482 needles/cm2 on the right side of the face under the eye. The treatments were applied for 12 weeks, with the assessment outcomes evaluated at the baseline and 2, 4, 6, 8, 10, and 12 weeks. Results: The application of these two novel MNP designs successfully rejuvenated under-eye wrinkles with low pain level scores. Increasing the length of the needle or having a 350 μm long MN can better reduce under-eye wrinkles without statistical significance. During the study period, there was an improvement in skin surface roughness in both groups accompanied by a consistent reduction in under-eye skin wrinkles, without statistically significant differences observed between the groups when using the Antera 3D system. 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引用次数: 0

摘要

背景:微针贴片(MNP)技术目前已应用于多种用途,包括经皮给药和美容及皮肤科领域的经皮胶原蛋白诱导。以前的研究表明,微针贴片能有效改善皮肤外观,而使用较大或较深的微针进行治疗则不易被人体接受。很少有研究对 MNP 的设计进行人体比较。研究目的:比较高长度、低密度和低长度、高密度的新型 MNP 设计在眼下皱纹嫩肤方面的效果。研究方法:这项非随机分脸临床试验是一项双盲研究,共有 36 名泰国女性参加。每位参与者都接受了两种不同微针设计的治疗,脸部两侧各一次。左脸眼下的微针长度为 250 μm,密度为 945 针/平方厘米;右脸眼下的微针长度为 350 μm,密度为 482 针/平方厘米。治疗持续 12 周,分别在基线期、2、4、6、8、10 和 12 周进行评估。结果这两种新型 MNP 设计成功地使眼下皱纹恢复年轻,且疼痛程度较低。增加针的长度或使用 350 μm 长的 MN 可以更好地减少眼底皱纹,但无统计学意义。在研究期间,使用 Antera 3D 系统时,两组的皮肤表面粗糙度都有所改善,眼底皮肤皱纹也持续减少,但两组之间没有统计学意义上的显著差异。不过,与针刺密度较高的短针(250 微米长的 MN)相比,350 微米长的 MN 也略微增加了疼痛感。两种设计均无副作用。结论这两种新型 MNPs 作为一种安全的非侵入性治疗方法,在眼下皮肤皱纹的年轻化方面取得了良好的效果。增加针的数量和延长针的长度都能有效安全地减少眼下皱纹,且无任何不良反应。此外,参与者还可以在家中自行施针,并对施针效果非常满意。不过,与增加针的数量相比,增加针的长度可能会稍稍增加疼痛感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Comparative Efficacy and Safety of 250 μm versus 350 μm Long Microneedle Patch on Under-Eye Skin
Background: Microneedle patch (MNP) technology is now applied for many purposes, including transdermal drug delivery and percutaneous collagen induction in the cosmetic and dermatology fields. Previous research showed that a MNP effectively improved skin appearance, while treatments using larger or deeper microneedles were not easily tolerated by human subjects. Few studies have compared MNP designs in humans. Study Objective: To compare novel MNP designs with high length and low density versus low length and high density for rejuvenating skin wrinkles under the eyes. Methods: This non-randomized split-face clinical trial was conducted as a double-blind study with 36 Thai female participants. Each participant was treated with two different MNP designs, one on each side of the face. The microneedle lengths were 250 μm with a density of 945 needles/cm2 on the left side of the face under the eye and 350 μm with a density of 482 needles/cm2 on the right side of the face under the eye. The treatments were applied for 12 weeks, with the assessment outcomes evaluated at the baseline and 2, 4, 6, 8, 10, and 12 weeks. Results: The application of these two novel MNP designs successfully rejuvenated under-eye wrinkles with low pain level scores. Increasing the length of the needle or having a 350 μm long MN can better reduce under-eye wrinkles without statistical significance. During the study period, there was an improvement in skin surface roughness in both groups accompanied by a consistent reduction in under-eye skin wrinkles, without statistically significant differences observed between the groups when using the Antera 3D system. However, the 350 μm long MN also slightly increased the pain compared to the shorter needles (250 μm long MN) with a higher density of needles. There were no side effects associated with the two designs. Conclusions: The two novel MNPs gave favorable results as a safe non-invasive treatment for the rejuvenation of skin wrinkles under the eyes. Increasing the number of needles and increasing the length of the needles were both effective in safely reducing under-eye wrinkles without any adverse effects. Additionally, participants could self-apply them at home and were highly satisfied. However, increasing the length of the needles may result in slightly more pain compared to increasing the number of needles.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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