{"title":"食道恶性肿瘤的临床病理学研究，特别关注 HER2/Neu 的免疫组化表达","authors":"Ramya Katta, Pasam Ramana Kumari, Bora Sreedhar","doi":"10.1177/09760016241258043","DOIUrl":null,"url":null,"abstract":"Oesophageal malignancies tend to have poor prognosis and thus there is a need to identify newer therapeutic targets for their treatment. This study aimed at studying the incidence and histopathological spectrum of oesophageal malignancies with special emphasis on immunohistochemical expression of HER2/Neu in adenocarcinomas. This study was a retrospective descriptive study conducted in a tertiary care centre in South India. Endoscopic biopsies and resection specimens of oesophageal malignancies were included in the study. Immunohistochemical analysis for HER2/Neu was performed on all oesophageal adenocarcinomas. Squamous cell carcinoma constituted the most common malignancy in this study. Approximately 20% of oesophageal adenocarcinomas showed positivity for HER2/Neu. A prominent association of Barrett’s metaplasia with oesophageal adenocarcinoma was noted.","PeriodicalId":34670,"journal":{"name":"Apollo Medicine","volume":" 8","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Clinicopathological Study of Oesophageal Malignancies With Special Reference to Immunohistochemical Expression of HER2/Neu\",\"authors\":\"Ramya Katta, Pasam Ramana Kumari, Bora Sreedhar\",\"doi\":\"10.1177/09760016241258043\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Oesophageal malignancies tend to have poor prognosis and thus there is a need to identify newer therapeutic targets for their treatment. This study aimed at studying the incidence and histopathological spectrum of oesophageal malignancies with special emphasis on immunohistochemical expression of HER2/Neu in adenocarcinomas. This study was a retrospective descriptive study conducted in a tertiary care centre in South India. Endoscopic biopsies and resection specimens of oesophageal malignancies were included in the study. Immunohistochemical analysis for HER2/Neu was performed on all oesophageal adenocarcinomas. Squamous cell carcinoma constituted the most common malignancy in this study. Approximately 20% of oesophageal adenocarcinomas showed positivity for HER2/Neu. A prominent association of Barrett’s metaplasia with oesophageal adenocarcinoma was noted.\",\"PeriodicalId\":34670,\"journal\":{\"name\":\"Apollo Medicine\",\"volume\":\" 8\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Apollo Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/09760016241258043\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Apollo Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/09760016241258043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Clinicopathological Study of Oesophageal Malignancies With Special Reference to Immunohistochemical Expression of HER2/Neu
Oesophageal malignancies tend to have poor prognosis and thus there is a need to identify newer therapeutic targets for their treatment. This study aimed at studying the incidence and histopathological spectrum of oesophageal malignancies with special emphasis on immunohistochemical expression of HER2/Neu in adenocarcinomas. This study was a retrospective descriptive study conducted in a tertiary care centre in South India. Endoscopic biopsies and resection specimens of oesophageal malignancies were included in the study. Immunohistochemical analysis for HER2/Neu was performed on all oesophageal adenocarcinomas. Squamous cell carcinoma constituted the most common malignancy in this study. Approximately 20% of oesophageal adenocarcinomas showed positivity for HER2/Neu. A prominent association of Barrett’s metaplasia with oesophageal adenocarcinoma was noted.
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