K. Suzuki, O. Inoue, K. Hashimoto, T. Yamasaki, M. Kuchiki, K. Tamate
{"title":"计算机控制大规模生产高比活性[11C]RO 15-1788用于苯二氮卓类受体的PET研究","authors":"K. Suzuki, O. Inoue, K. Hashimoto, T. Yamasaki, M. Kuchiki, K. Tamate","doi":"10.1016/0020-708X(85)90258-3","DOIUrl":null,"url":null,"abstract":"<div><p>Ethyl 8-fluoro-5,6-dihydro-5-[<sup>11</sup>C]methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine-3-carboxylate ([<sup>11</sup>C]RO 15-1788) has been prepared automatically with high specific activity for <em>in vivo</em> visualization or quantitative analysis of brain benzodiazepine receptors. The yield, radiochemical yield, radiochemical purity and specific activity of the product ready for an i.v. injection were 276 ± 76 mCi, 50.8 ± 7.8%,99.3 ± 0.3% and 2.9 ± 0.5 Ci/<em>μ</em>mol, respectively, taking an average of the latest 3 runs. The time required was about 25 min. Each product was sufficient to carry out three successive clinical studies by positron emission tomography (PET). All the procedures other than evaporation and filtration at the final stage were carried out with specially designed equipment connected to a central control system for radioisotope production.</p></div>","PeriodicalId":22517,"journal":{"name":"The International journal of applied radiation and isotopes","volume":"36 12","pages":"Pages 971-976"},"PeriodicalIF":0.0000,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-708X(85)90258-3","citationCount":"99","resultStr":"{\"title\":\"Computer-controlled large scale production of high specific activity [11C]RO 15-1788 for PET studies of benzodiazepine receptors\",\"authors\":\"K. Suzuki, O. Inoue, K. Hashimoto, T. Yamasaki, M. Kuchiki, K. Tamate\",\"doi\":\"10.1016/0020-708X(85)90258-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Ethyl 8-fluoro-5,6-dihydro-5-[<sup>11</sup>C]methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine-3-carboxylate ([<sup>11</sup>C]RO 15-1788) has been prepared automatically with high specific activity for <em>in vivo</em> visualization or quantitative analysis of brain benzodiazepine receptors. The yield, radiochemical yield, radiochemical purity and specific activity of the product ready for an i.v. injection were 276 ± 76 mCi, 50.8 ± 7.8%,99.3 ± 0.3% and 2.9 ± 0.5 Ci/<em>μ</em>mol, respectively, taking an average of the latest 3 runs. The time required was about 25 min. Each product was sufficient to carry out three successive clinical studies by positron emission tomography (PET). All the procedures other than evaporation and filtration at the final stage were carried out with specially designed equipment connected to a central control system for radioisotope production.</p></div>\",\"PeriodicalId\":22517,\"journal\":{\"name\":\"The International journal of applied radiation and isotopes\",\"volume\":\"36 12\",\"pages\":\"Pages 971-976\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0020-708X(85)90258-3\",\"citationCount\":\"99\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International journal of applied radiation and isotopes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0020708X85902583\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of applied radiation and isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020708X85902583","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Computer-controlled large scale production of high specific activity [11C]RO 15-1788 for PET studies of benzodiazepine receptors
Ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine-3-carboxylate ([11C]RO 15-1788) has been prepared automatically with high specific activity for in vivo visualization or quantitative analysis of brain benzodiazepine receptors. The yield, radiochemical yield, radiochemical purity and specific activity of the product ready for an i.v. injection were 276 ± 76 mCi, 50.8 ± 7.8%,99.3 ± 0.3% and 2.9 ± 0.5 Ci/μmol, respectively, taking an average of the latest 3 runs. The time required was about 25 min. Each product was sufficient to carry out three successive clinical studies by positron emission tomography (PET). All the procedures other than evaporation and filtration at the final stage were carried out with specially designed equipment connected to a central control system for radioisotope production.
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