金属络合物和卟啉的抗炎和抗血栓潜力

Compounds Pub Date : 2024-06-10 DOI:10.3390/compounds4020023
A. Tsoupras, Sofia Pafli, Charilaos Stylianoudakis, K. Ladomenou, C. Demopoulos, A. Philippopoulos
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引用次数: 0

摘要

炎症和血栓形成与多种慢性疾病有关。最近的研究概述了几种化合物如何提供抗炎保护。本综述全面介绍了迄今为止报道的几种金属基复合物在体外和体内的抗炎健康促进作用。这些金属基复合物通常会干扰与炎症反应和血栓形成相关的各种生化过程,并能够抑制这些生化途径,从而对健康有益。重点介绍了金属基复合物的多方面作用,这些复合物对炎症介质血小板活化因子(PAF)及其血栓-炎症信号传导具有强大的抗炎和抗血栓活性,同时还具有抗血小板和抗肿瘤的健康促进特性。此外,还讨论了通过在几种金属基复合物中加入配体来增强成熟生物活性化合物的抗炎功效。此外,还概述了含有天然抗炎生物活性成分的金属基复合物。还探讨了游离卟啉和金属基卟啉的特征性实例。这些化合物被认为具有抗炎和抗血栓作用,此外还具有其他多效应优势,包括抗菌或抗癌作用。此外,还展示了金属复合物在各种炎症和血栓并发症模型中的应用。本研究的综合结果表明,需要进一步研究制备具有更好药理特征的多种金属基复合物。最后,还介绍了这些金属基化合物的应用限制、未来前景以及为提高其疗效和安全性而进行更多研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-Inflammatory and Antithrombotic Potential of Metal-Based Complexes and Porphyrins
Inflammation and thrombosis are implicated in several chronic disorders. Recent studies have outlined the way in which several compounds can offer protection against inflammation. Within this comprehensive review the so-far reported anti-inflammatory health-promoting effects of several metal-based complexes, both in vitro and in vivo, are thoroughly presented. These metal-based compounds usually interfere with various biochemical processes associated with the inflammatory response and thrombus formation and become capable of inhibiting these biochemical pathways with proposed health benefits. Emphasis is given to the multifaceted actions of metal-based complexes that have exhibited potent anti-inflammatory and antithrombotic activities against the inflammatory mediator, platelet-activating factor (PAF), and its thrombo-inflammatory signaling, as well as on their anti-platelet and antitumor health promoting properties. Furthermore, the enhancement of the anti-inflammatory potency of well-established bioactive compounds by their incorporation as ligands in several metal-based complexes is discussed. Metal-based complexes bearing natural anti-inflammatory bioactives are also outlined. Characteristic examples of both free and metal-based porphyrins are explored. These compounds are recognized to have anti-inflammatory and antithrombotic assets, in addition to other pleiotropic advantages including antibacterial or anticancer actions. Additionally, applications of metal complexes in various models of inflammatory and thrombotic complications are demonstrated. The combined results of this study show that further research is required towards the preparation of several metal-based complexes with improved pharmacological profiles. Finally, restrictions on the application of these metal-based compounds are also covered, along with their prospects for the future and the need for additional study in order to improve their efficacy and safety.
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