中国成年人血清中 25- 羟维生素 D 与血脂之间的非线性关系

Qianqian Wang, Xinlei Miao, Manling Hu, Fei Xu, Guimin Tang, Yangxuan He, Ziping Song, Wan Zhao, Xiangjun Niu, Song Leng
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摘要

以往关于血清 25- 羟基维生素 D [25(OH)D] 水平与血脂曲线之间关系的研究显示,两者之间的关系并不明确。本研究从大连健康管理队列(DHMC)中招募了8516名成年参与者(年龄在18-74岁之间,男性3750人,女性4766人)。在对年龄、性别、季节和紫外线指数进行调整后,采用逻辑回归法、限制性三次样条回归法和分段线性回归法估算了不同血清 25(OH)D 水平下特定血脂异常的风险(OR),并确定了血清 25(OH)D 的临界值。25(OH)D 的水平与血脂异常的风险(ORs)呈反 U 型相关,高胆固醇血症的拐点为 23.7 纳克/毫升,高甘油三酯血症的拐点为 24.3 纳克/毫升,高甘油三酯血症的拐点为 18.5 纳克/毫升。5 ng/ml、低高密度脂蛋白胆固醇血症 23.3 ng/ml、高非高密度脂蛋白胆固醇 23.3 ng/ml、高残余胆固醇 24.3 ng/ml。分层分析表明,与缺乏 25(OH)D 有关的大多数血脂异常的风险在 50-74 岁女性中特别高(高甘油三酯血症除外,50-74 岁男性的风险最高),在冬季/春季或在低/中紫外线指数环境下特别高。在 50-74 岁女性、冬春季节或紫外线指数较低的环境中,这种风险尤其增加。在维生素 D 缺乏的受试者中[25(OH)D <20 纳克/毫升],血清维生素 D 水平与血脂异常的风险呈正相关,这需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nonlinear relationship between serum 25-hydroxyvitamin D and lipid profile in Chinese adults
Previous studies on the liner associations between serum 25-hydroxyvitamin D [25(OH)D] levels and lipid profiles revealed ambiguous findings. The current study therefore tried to elucidate the possible non-linear associations between 25(OH)D and lipid profiles.This study involved 8,516 adult participants (aged 18–74 years, males N = 3,750, females N = 4,766) recruited from the Dalian health management cohort (DHMC). The risk (OR) for specific dyslipidemias was estimated across the serum 25(OH)D levels and the cut-off value for serum 25(OH)D were determined by using logistic regression, restricted cubic spline, and piecewise linear regression methods, adjusted for age, sex, season, and ultraviolet index.In this study, a high prevalence of 25(OH)D deficiency was observed in the participants (65.05%). The level of 25(OH)D showed the inverse U-shaped correlations with the risks (ORs) of abnormal lipid profile, with inflection points observed at 23.7 ng/ml for hypercholesterolemia, 24.3 ng/ml for hypertriglyceridemia, 18.5 ng/ml for hyper-low-density lipoprotein cholesterolemia, 23.3 ng/ml for hypo-high-density lipoprotein cholesterolemia, 23.3 ng/ml for hyper-non-high-density lipoprotein cholesterol, and 24.3 ng/ml for high remnant cholesterol. The stratified analyses showed that the risk for most dyslipidemias related to deficiency of 25(OH)D was particularly increased among females aged 50–74 (except for hypertriglyceridemia, where the highest risk was among men aged 50–74 years), during winter/spring or under low/middle ultraviolet index environments.Nonlinear inverse U-shaped associations were observed between 25(OH)D levels and abnormal lipid profile. The risk was particularly increased among females aged 50-74, during winter/spring period or under lower ultraviolet index environments. In vitamin D deficient subjects [25(OH)D <20 ng/ml], a positive association of serum vitamin D levels with the risk for dyslipidemia was observed, which needs a further.
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