尼日利亚老年 2 型糖尿病患者微血管并发症的发生率、模式和潜在预测因素

William Balogun, M. Emuze, Lawrence Adebusoye, Olufemi O Olowookere
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摘要

在尼日利亚等资源匮乏的国家,糖尿病患病率不断上升的同时,糖尿病微血管并发症也造成了过重的负担。本研究旨在确定老年糖尿病患者微血管并发症的发病率和预测因素。因此,我们在托尼-阿内尼老年病中心主任糖尿病门诊对老年糖尿病患者进行了一项为期两年的回顾性横断面研究。研究共纳入了 148 名糖尿病患者;平均年龄(± 标准差)为 70.89(± 6.99)岁,71.6% 的研究对象为女性。研究采用逻辑回归分析来确定微血管并发症的患病率和预测因素。结果显示,老年糖尿病患者微血管并发症的发病率为 73.9% [95% 置信区间 (CI)=66.7-81.6] ,其中最常见的是周围神经病变(发病率为 77.1%,95% CI=67.9-84.8),而视网膜病变的发病率最低(95% CI=4.7-16.8)。仅口服药物[p=0.013,比值比(OR)=2.35,95% CI=1.15-16.81]、合并症数量(p=0.041,调整后 OR=5.28,95% CI=1.09-27.93)和收缩压(p=0.042,OR=1.02,95% CI=1.00-1.04)是微血管并发症的重要预测因素。考虑到微血管并发症在老年糖尿病患者中的高发率,老年患者应遵医嘱口服药物并定期检查,同时应加强宣传,强化老年医疗保健系统,以减轻并发症,减少并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence, pattern, and potential predictors of microvascular complications in aging Nigerians with type 2 diabetes
In low-resource settings like Nigeria, the rising prevalence of diabetes is accompanied by an excessive burden of microvascular complications from diabetes. This study aimed to determine the prevalence and predictors of microvascular complications among older patients with diabetes mellitus. Therefore, a 2-year retrospective cross-sectional study was carried out among elderly diabetes patients at the Chief Tony Anenih Geriatric Center outpatient diabetes clinic. A total of 148 diabetic patients were included in the study; the mean (± standard deviation) age was 70.89 (±6.99) years, with 71.6% of the studied population being female. Logistic regression analysis was employed to determine the prevalence and predictors of microvascular complications. Results show that the prevalence of microvascular complications in older diabetes patients was 73.9% [95% confidence interval (CI)=66.7-81.6] with peripheral neuropathy (77.1% prevalence, 95% CI=67.9-84.8) being the most common and retinopathy being the least prevalent (95% CI=4.7-16.8). The significant predictors of developing microvascular complications were intake of oral agents only [p=0.013, odds ratio (OR)=2.35, 95% CI=1.15-16.81], number of comorbidities (p=0.041, adjusted OR=5.28, 95% CI=1.09-27.93) and systolic blood pressure (p=0.042, OR=1.02, 95% CI=1.00-1.04). Considering the high prevalence of microvascular complications among aging patients with diabetes mellitus, older patients should comply with oral medications and undergo regular check-ups, and more advocacy should be undertaken to strengthen geriatric healthcare systems to mitigate comorbidities and reduce complications.
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