Zexin Fan, Chao Wu, Chaobin Wang, Chun Liu, Libo Fang, Lin Ma, Wenlong Zou, Boyi Yuan, Zeyu Ji, Bin Cai, Guangzhi Liu
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Clinical data were obtained from medical records, and all participants were followed up in the outpatient clinic or by telephone for at least 1 year. A Cox proportional hazards model and Kaplan–Meier curves were used to evaluate the effects of concurrent IS on the prognosis of patients with DCM. Results : Patients with DCM complicated with IS (DCM-IS) had significantly lower cumulative survival rates than patients with DCM without IS (non-IS) (74.6% vs. 84.2%, χ 2 = 6.85, p = 0.009). Additionally, IS was associated with greater risks of death and heart transplantation (HTx) in men (75.8% vs. 85.1%, χ 2 = 5.02, p = 0.025), but not in women (71.0% vs. 81.5%, χ 2 = 1.91, p = 0.167). Conclusions : This large-scale multicentre prospective cohort study demonstrated a poorer prognosis in patients with concurrent DCM and IS, particularly among men. Patients with DCM should not be overlooked in IS screening, emphasis should be placed on the occurrence of IS in patients with DCM. Early and proactive secondary prevention of cerebrovascular diseases might improve the prognosis of DCM patients. More intervention studies focusing on men with DCM complicated with IS should be prioritised.","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Concurrent Ischaemic Stroke on Unfavourable Outcomes in Men and Women with Dilated Cardiomyopathy\",\"authors\":\"Zexin Fan, Chao Wu, Chaobin Wang, Chun Liu, Libo Fang, Lin Ma, Wenlong Zou, Boyi Yuan, Zeyu Ji, Bin Cai, Guangzhi Liu\",\"doi\":\"10.31083/j.rcm2506215\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background : Growing evidence suggests that concurrent ischaemic stroke (IS) exacerbates the prognosis of patients with dilated cardiomyopathy (DCM) and that this effect may be further influenced by sex. However, the exact effect of sex remains unclear. 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Additionally, IS was associated with greater risks of death and heart transplantation (HTx) in men (75.8% vs. 85.1%, χ 2 = 5.02, p = 0.025), but not in women (71.0% vs. 81.5%, χ 2 = 1.91, p = 0.167). Conclusions : This large-scale multicentre prospective cohort study demonstrated a poorer prognosis in patients with concurrent DCM and IS, particularly among men. Patients with DCM should not be overlooked in IS screening, emphasis should be placed on the occurrence of IS in patients with DCM. Early and proactive secondary prevention of cerebrovascular diseases might improve the prognosis of DCM patients. 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引用次数: 0
摘要
背景:越来越多的证据表明,并发缺血性卒中(IS)会加重扩张型心肌病(DCM)患者的预后,而且这种影响可能会受到性别的进一步影响。然而,性别的确切影响仍不清楚。本研究旨在探讨相关风险因素对 DCM 和并发 IS 患者预后的影响。考虑到 DCM 的性别差异,本研究进一步探讨了并发 IS 对男性和女性 DCM 患者预后的影响。方法:本研究共纳入了 632 名在 2016 年至 2021 年间入院的 DCM 患者。临床数据来自病历,所有参与者均在门诊或通过电话接受了至少一年的随访。采用Cox比例危险模型和Kaplan-Meier曲线评估并发IS对DCM患者预后的影响。结果:并发 IS 的 DCM 患者(DCM-IS)的累积生存率明显低于未并发 IS 的 DCM 患者(非 IS)(74.6% 对 84.2%,χ 2 = 6.85,P = 0.009)。此外,IS与男性(75.8% vs. 85.1%,χ 2 = 5.02,p = 0.025)更高的死亡和心脏移植(HTx)风险有关,但与女性(71.0% vs. 81.5%,χ 2 = 1.91,p = 0.167)无关。结论 :这项大规模多中心前瞻性队列研究表明,并发 DCM 和 IS 的患者预后较差,尤其是男性患者。在 IS 筛查中不应忽视 DCM 患者,应重视 DCM 患者 IS 的发生。早期、积极地进行脑血管疾病的二级预防可改善 DCM 患者的预后。应优先考虑对并发 IS 的男性 DCM 患者进行更多干预研究。
Impact of Concurrent Ischaemic Stroke on Unfavourable Outcomes in Men and Women with Dilated Cardiomyopathy
Background : Growing evidence suggests that concurrent ischaemic stroke (IS) exacerbates the prognosis of patients with dilated cardiomyopathy (DCM) and that this effect may be further influenced by sex. However, the exact effect of sex remains unclear. This study aimed to explore the effects of the relevant risk factors on the prognosis of patients with DCM and concurrent IS. Considering the sex differences in DCM, this study further investigated the impact of concurrent IS on the prognosis of men and women with DCM. Methods : A total of 632 patients with DCM enrolled between 2016 and 2021 were included in this study. Clinical data were obtained from medical records, and all participants were followed up in the outpatient clinic or by telephone for at least 1 year. A Cox proportional hazards model and Kaplan–Meier curves were used to evaluate the effects of concurrent IS on the prognosis of patients with DCM. Results : Patients with DCM complicated with IS (DCM-IS) had significantly lower cumulative survival rates than patients with DCM without IS (non-IS) (74.6% vs. 84.2%, χ 2 = 6.85, p = 0.009). Additionally, IS was associated with greater risks of death and heart transplantation (HTx) in men (75.8% vs. 85.1%, χ 2 = 5.02, p = 0.025), but not in women (71.0% vs. 81.5%, χ 2 = 1.91, p = 0.167). Conclusions : This large-scale multicentre prospective cohort study demonstrated a poorer prognosis in patients with concurrent DCM and IS, particularly among men. Patients with DCM should not be overlooked in IS screening, emphasis should be placed on the occurrence of IS in patients with DCM. Early and proactive secondary prevention of cerebrovascular diseases might improve the prognosis of DCM patients. More intervention studies focusing on men with DCM complicated with IS should be prioritised.
期刊介绍:
RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.