68 Ga-FAPI PET/CT 与 18 F-FDG PET/CT：在一例乳腺癌/获得性免疫缺陷综合征病例中区分转移性疾病和反应性淋巴结

IF 0.6 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

World Journal of Nuclear Medicine Pub Date : 2024-06-14 DOI:10.1055/s-0044-1787718

Gopinathraj Gunasekaran, Jaykanth Amalachandran

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引用次数: 0

摘要

摘要镓-68（68 Ga）-成纤维细胞活化蛋白抑制剂（FAPI）正电子发射断层扫描（PET）可对构成肿瘤微环境重要组成部分的癌症相关成纤维细胞进行成像。众所周知，68 Ga-FAPI PET 可以帮助区分反应性淋巴结和转移性淋巴结。18 F-氟脱氧葡萄糖（FDG）PET/计算机断层扫描（CT）仍是评估包括乳腺癌在内的多种恶性肿瘤最常用的 PET 放射性药物。反应性淋巴结也可能显示 FDG 摄取，这可能会妨碍对转移受累的最佳评估。我们报告了一例有趣的右乳腺浸润性导管癌病例，该病例伴有世界卫生组织临床 I 期获得性免疫缺陷综合征，我们对其进行了 18 F-FDG PET/CT 和 68 Ga-FAPI PET/CT。

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68 Ga-FAPI PET/CT versus 18 F-FDG PET/CT: Differentiating Metastatic Disease and Reactive Lymph Nodes in a Case of Carcinoma of Breast/Acquired Immunodeficiency Syndrome

Abstract Gallium-68 ( 68 Ga)-fibroblast activation protein inhibitor (FAPI) positron emission tomography (PET) images the cancer-associated fibroblast that forms a vital component of the tumor microenvironment. It is known that 68 Ga-FAPI PET can aid in differentiating reactive lymph nodes from metastatic lymph nodes. 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) is still the most commonly used PET radiopharmaceutical in the evaluation of a wide range of malignancies including breast carcinoma. Reactive lymph nodes may also show FDG uptake which can hinder optimal assessment for metastatic involvement. We report an interesting case of invasive ductal carcinoma of the right breast with associated World Health Organization clinical stage I acquired immunodeficiency syndrome for which 18 F-FDG PET/CT and 68 Ga-FAPI PET/CT were done.

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来源期刊

World Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

16.70%

发文量

118

审稿时长

48 weeks