催产素对疼痛的调节

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Peptides Pub Date : 2024-06-17 DOI:10.1016/j.peptides.2024.171263

Makoto Kawasaki , Akinori Sakai , Yoichi Ueta

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引用次数: 0

摘要

催产素（OXT）于 1906 年被发现，是一种促进怀孕和分娩的物质。它影响子宫收缩和泌乳。此外，催产素的生理特性之一是具有镇痛作用。生物体内有一条从外周向中枢传递疼痛刺激的上升通路和一条从中枢上部向下调节背角神经元的下降通路。OXT 参与抑制疼痛的下降通路，通常被认为具有镇痛作用。在本文中，我们将介绍 OXT 在众多生理作用中的镇痛作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pain modulation by oxytocin

Oxytocin (OXT) was discovered in 1906 as a substance that promotes the pregnancy and childbirth. It affects uterine contraction and lactation. Furthermore, as one of its physiological properties, it exerts analgesic effects. The living body has an ascending pathway that transmits pain stimuli from the periphery to the center and a descending pathway that regulates the dorsal horn neurons from the upper center downward. OXT is involved in the pain-inhibitory descending pathway and generally assumed to exert analgesic effects. In this article, we describe the pain-suppressive effects of OXT, among its many physiological effects.

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来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.