Benson Musinguzi, Ekwaro A Obuku, Alison Annet Kinengyere, Regina Ndagire, Andrew Baguma, Alex Mwesigwa, Herbert Itabangi, Gerald Mboowa, Obondo James Sande, Beatrice Achan
{"title":"非洲人类免疫缺陷病毒感染者口咽念珠菌病患病率和念珠菌种类分布：系统回顾和荟萃分析。","authors":"Benson Musinguzi, Ekwaro A Obuku, Alison Annet Kinengyere, Regina Ndagire, Andrew Baguma, Alex Mwesigwa, Herbert Itabangi, Gerald Mboowa, Obondo James Sande, Beatrice Achan","doi":"10.21203/rs.3.rs-4534730/v1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The incidence of oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa is on the rise. Oropharyngeal candidiasis is mainly caused by <i>C.albicans</i>; however, a shift in the etiology towards non-<i>Candida albicans</i> species is increasing. In addition, there are variations in the epidemiological distribution of <i>Candida</i> species causing oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa.</p><p><strong>Objective: </strong>This review aimed to determine the prevalence of oropharyngeal candidiasis and the distribution of <i>Candida</i> species among people living with human immunodeficiency virus in Africa.</p><p><strong>Materials and methods: </strong>This systematic review protocol was registered in the base PROSPERO database prior to its conduct (CRD42021254473). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol guidelines (PRISMA-P) were followed for this study. The PubMed, Scopus and EMBASE databases were searched to identify published studies published between 1<sup>st</sup> January 2000 and 8<sup>th</sup> October 2022. The eligible studies were included in the meta-analysis and analyzed using a random effects model. The risk of bias of the included studies was assessed using the Joanna Briggs Institute quality assessment tool for prevalence studies.</p><p><strong>Results: </strong>The database search yielded 370 titles from PubMed (n=192), EMBASE (n=162) and SCOPUS (n=16). Fourteen studies with a total of 3,863 participants were included in the meta-analysis. The pooled prevalence of oropharyngeal candidiasis was 49.0% (95% CI: 37% - 62%). A total of 2,688 <i>Candida</i> isolates were reported; approximately 76.6% (n=2,060) were <i>C. albicans</i>, and 21.7% (n=582) were non-<i>C. albicans</i>. Among the non-<i>Candida albicans</i> species, <i>C</i>. <i>glabrata</i> was the most common isolate (29.6%), followed by <i>C</i>. <i>tropicalis</i> (27.7%), <i>C</i>. <i>krusei</i> (17.0%), <i>C</i>. <i>parapsilosis</i> (8.1%) and <i>C</i>. <i>dubliniensis</i> (5.2%). Out of 14 studies, 7 (50.0%) had a low risk of bias, 5 (35.7%) had a moderate risk of bias, and 2 (14.3%) had a high risk of bias.</p><p><strong>Conclusion: </strong>Almost half of people living with HIV in Africa have oropharyngeal candidiasis, and <i>C. albicans</i> remains the most frequent cause of oropharyngeal candidiasis.</p>","PeriodicalId":94282,"journal":{"name":"Research square","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177986/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of Oropharyngeal Candidiasis and distribution of <i>Candida</i> species among People Living with Human Immunodeficiency Virus in Africa: a systematic review and meta-analysis.\",\"authors\":\"Benson Musinguzi, Ekwaro A Obuku, Alison Annet Kinengyere, Regina Ndagire, Andrew Baguma, Alex Mwesigwa, Herbert Itabangi, Gerald Mboowa, Obondo James Sande, Beatrice Achan\",\"doi\":\"10.21203/rs.3.rs-4534730/v1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The incidence of oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa is on the rise. Oropharyngeal candidiasis is mainly caused by <i>C.albicans</i>; however, a shift in the etiology towards non-<i>Candida albicans</i> species is increasing. In addition, there are variations in the epidemiological distribution of <i>Candida</i> species causing oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa.</p><p><strong>Objective: </strong>This review aimed to determine the prevalence of oropharyngeal candidiasis and the distribution of <i>Candida</i> species among people living with human immunodeficiency virus in Africa.</p><p><strong>Materials and methods: </strong>This systematic review protocol was registered in the base PROSPERO database prior to its conduct (CRD42021254473). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol guidelines (PRISMA-P) were followed for this study. The PubMed, Scopus and EMBASE databases were searched to identify published studies published between 1<sup>st</sup> January 2000 and 8<sup>th</sup> October 2022. The eligible studies were included in the meta-analysis and analyzed using a random effects model. The risk of bias of the included studies was assessed using the Joanna Briggs Institute quality assessment tool for prevalence studies.</p><p><strong>Results: </strong>The database search yielded 370 titles from PubMed (n=192), EMBASE (n=162) and SCOPUS (n=16). Fourteen studies with a total of 3,863 participants were included in the meta-analysis. The pooled prevalence of oropharyngeal candidiasis was 49.0% (95% CI: 37% - 62%). A total of 2,688 <i>Candida</i> isolates were reported; approximately 76.6% (n=2,060) were <i>C. albicans</i>, and 21.7% (n=582) were non-<i>C. albicans</i>. Among the non-<i>Candida albicans</i> species, <i>C</i>. <i>glabrata</i> was the most common isolate (29.6%), followed by <i>C</i>. <i>tropicalis</i> (27.7%), <i>C</i>. <i>krusei</i> (17.0%), <i>C</i>. <i>parapsilosis</i> (8.1%) and <i>C</i>. <i>dubliniensis</i> (5.2%). Out of 14 studies, 7 (50.0%) had a low risk of bias, 5 (35.7%) had a moderate risk of bias, and 2 (14.3%) had a high risk of bias.</p><p><strong>Conclusion: </strong>Almost half of people living with HIV in Africa have oropharyngeal candidiasis, and <i>C. albicans</i> remains the most frequent cause of oropharyngeal candidiasis.</p>\",\"PeriodicalId\":94282,\"journal\":{\"name\":\"Research square\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177986/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research square\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21203/rs.3.rs-4534730/v1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research square","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21203/rs.3.rs-4534730/v1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prevalence of Oropharyngeal Candidiasis and distribution of Candida species among People Living with Human Immunodeficiency Virus in Africa: a systematic review and meta-analysis.
Background: The incidence of oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa is on the rise. Oropharyngeal candidiasis is mainly caused by C.albicans; however, a shift in the etiology towards non-Candida albicans species is increasing. In addition, there are variations in the epidemiological distribution of Candida species causing oropharyngeal candidiasis among people living with human immunodeficiency virus in Africa.
Objective: This review aimed to determine the prevalence of oropharyngeal candidiasis and the distribution of Candida species among people living with human immunodeficiency virus in Africa.
Materials and methods: This systematic review protocol was registered in the base PROSPERO database prior to its conduct (CRD42021254473). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol guidelines (PRISMA-P) were followed for this study. The PubMed, Scopus and EMBASE databases were searched to identify published studies published between 1st January 2000 and 8th October 2022. The eligible studies were included in the meta-analysis and analyzed using a random effects model. The risk of bias of the included studies was assessed using the Joanna Briggs Institute quality assessment tool for prevalence studies.
Results: The database search yielded 370 titles from PubMed (n=192), EMBASE (n=162) and SCOPUS (n=16). Fourteen studies with a total of 3,863 participants were included in the meta-analysis. The pooled prevalence of oropharyngeal candidiasis was 49.0% (95% CI: 37% - 62%). A total of 2,688 Candida isolates were reported; approximately 76.6% (n=2,060) were C. albicans, and 21.7% (n=582) were non-C. albicans. Among the non-Candida albicans species, C. glabrata was the most common isolate (29.6%), followed by C. tropicalis (27.7%), C. krusei (17.0%), C. parapsilosis (8.1%) and C. dubliniensis (5.2%). Out of 14 studies, 7 (50.0%) had a low risk of bias, 5 (35.7%) had a moderate risk of bias, and 2 (14.3%) had a high risk of bias.
Conclusion: Almost half of people living with HIV in Africa have oropharyngeal candidiasis, and C. albicans remains the most frequent cause of oropharyngeal candidiasis.
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