A 型肉毒毒素和微波热解治疗腋下多汗症的亚临床效应:利用线场共聚焦光学相干断层扫描和组织学进行的描述性研究。

IF 3.5 3区 医学 Q1 DERMATOLOGY
Gabriela Lladó Grove, Kevin Jacobsen, Nina Loeth Maartensson, Merete Haedersdal
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引用次数: 0

摘要

肉毒杆菌毒素 A(BTX)和微波热解(MWT)是标准的腋下多汗症治疗方法,但缺乏对其亚临床效果的比较。线场共聚焦光学相干断层扫描(LC-OCT)是一种很有前景的非侵入性成像工具,可用于观察组织间的相互作用。本研究旨在通过 LC-OCT 成像与组织学相比,描述 BTX 和 MWT 治疗腋下多汗症的亚临床效应。这项研究来自于一项个体内随机对照试验,即使用 BTX 和 MWT 治疗腋窝多汗症。根据基线和 6 个月随访的 LC-OCT 图像(n = 8 名患者)对亚临床效应进行了评估,并与相应的组织学样本进行了比较。基线时,LC-OCT 可观察到皮肤表面的肾上腺毛孔和真皮上部(500 μm)的导管,但无法观察到深层的汗腺。组织学检查发现了整个汗腺。治疗后六个月,LC-OCT 发现任何 BTX 治疗过的腋窝(100%)都没有可检测到的形态变化,而大多数 MWT 治疗过的腋窝(75%)都能识别出阻塞的肾小球毛孔和萎缩的肾小球导管。组织学检查证实了LC-OCT的发现,同时还显示整个汗腺发生了实质性变化。MWT治疗后,LC-OCT可观察到浅表肾上腺皮质导管的亚临床改变,而BTX治疗后,其形态保持不变。LC-OCT 是一种很有前途的工具,可用于对特定治疗的组织相互作用进行无创评估,是组织学的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Subclinical effects of botulinum toxin A and microwave thermolysis for axillary hyperhidrosis: A descriptive study with line-field confocal optical coherence tomography and histology

Subclinical effects of botulinum toxin A and microwave thermolysis for axillary hyperhidrosis: A descriptive study with line-field confocal optical coherence tomography and histology

Botulinum toxin A (BTX) and microwave thermolysis (MWT) are standard axillary hyperhidrosis treatments, but comparison of their subclinical effects is lacking. Line-field confocal optical coherence tomography (LC-OCT) is a promising non-invasive imaging tool for visualizing tissue-interactions. This study aimed to describe subclinical effects of BTX and MWT for axillary hyperhidrosis with LC-OCT-imaging compared to histology. This study derived from an intra-individual, randomized, controlled trial, treating axillary hyperhidrosis with BTX versus MWT. Subclinical effects based on LC-OCT images from baseline and 6-month follow-up (n = 8 patients) were evaluated and compared to corresponding histological samples. At baseline, LC-OCT visualized eccrine pores at the skin surface and ducts in the upper dermis (500 μm), but not deeper-lying sweat glands. Histology identified entire sweat glands. Six months post-treatment, LC-OCT revealed no detectable morphology changes in any BTX-treated axillae (100%), while recognizing obstructed eccrine pores and atrophy of eccrine ducts in most MWT-treated axillae (75%). Histology corroborated LC-OCT findings, while also showing substantial changes to entire sweat glands. LC-OCT enabled visualization of subclinical alterations of superficial eccrine ducts after MWT and unchanged morphology after BTX. LC-OCT is a promising tool for non-invasive assessment of treatment-specific tissue-interactions that can be complementary to histology.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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