皮洛卡品全身治疗后大鼠癫痫发作频率和脑桥神经元缺失的品系差异。

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Epilepsy Research Pub Date : 2024-06-13 DOI:10.1016/j.eplepsyres.2024.107384

Kristina Junghans , Megan Wyeth , Paul S. Buckmaster

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引用次数: 0

摘要

在使用皮洛卡品全身治疗诱发癫痫状态至少 3 个月后，对 Long-Evans 大鼠和 Sprague-Dawley 大鼠进行为期 1 个月的癫痫发作连续视频脑电图监测。然后对大鼠进行灌注，对海马进行尼氏染色处理，并对海马神经元进行量化。Long-Evans 大鼠的癫痫发作频率是 Sprague-Dawley 大鼠的 1/10，而且变化更多。长-埃文斯大鼠的脑室神经元缺失程度也较轻。然而，这两个品系的大鼠脑室神经元缺失与癫痫发作频率之间没有相关性。癫痫发作频率低且不稳定，这表明经皮洛卡平处理的长伊万大鼠在某些癫痫实验中的作用有限。

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Rat strain differences in seizure frequency and hilar neuron loss after systemic treatment with pilocarpine

At least 3 months after systemic treatment with pilocarpine to induce status epilepticus, Long-Evans and Sprague-Dawley rats were video-EEG monitored for seizures continuously for 1 month. Rats were then perfused, hippocampi were processed for Nissl staining, and hilar neurons were quantified. Seizure frequency in Long-Evans rats was 1/10th of that in Sprague-Dawley rats, and more variable. Hilar neuron loss was also less severe in Long-Evans rats. However, there was no correlation between hilar neuron loss and seizure frequency in either strain. The low and variable seizure frequency suggests limited usefulness of pilocarpine-treated Long-Evans rats for some epilepsy experiments.

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.