ATRA通过RARα/Pitx2信号通路调节肌母细胞分化和融合,导致ARM胎鼠PFM发育异常。

IF 2.5 3区 生物学 Q2 DEVELOPMENTAL BIOLOGY
Hanbin Zhao, Jian Cao, Huaqi Mu, Yang Bi, Yuan Shi, Yi Wang
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引用次数: 0

摘要

肛门直肠畸形(ARM)是新生儿中最常见的先天性消化道畸形,ARM患儿往往存在不同程度的盆底肌肉(PFM)发育不全。为了探索RARα和Pitx2对大鼠盆底肌发育的影响,我们利用全反式维甲酸(ATRA)构建了大鼠ARM动物模型,并验证了RARα和Pitx2在胎鼠盆底肌中的表达。此外,我们还利用大鼠肌母细胞(L6细胞)研究了RARα和Pitx2在骨骼肌肌母细胞分化中的调控作用及其相互作用。结果表明,RARα和Pitx2在ARM胎鼠PFM中的表达明显下降。ATRA也能降低L6细胞中RARα和Pitx2的表达,同时影响L6细胞的分化和融合。在L6细胞中敲除RARα会降低Pitx2、MYOD1和MYMK的表达,并降低L6细胞的成肌活性。当 RARα 被激活时,Pitx2、MYOD1 和 MYMK 的表达减少以及成肌分化可在不同程度上得到恢复。同时,增加或抑制 Pitx2 的表达可分别抵消敲除 RARα 和激活 RARα 的影响。这些结果表明,Pitx2可能是转录因子RARα的下游,介导了ATRA对胎鼠PFM发育的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WITHDRAWN: ATRA regulates myoblast differentiation and fusion through the RARα/Pitx2 signaling pathway, causing abnormal development of PFMs in ARM fetal rats.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal.

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来源期刊
Developmental biology
Developmental biology 生物-发育生物学
CiteScore
5.30
自引率
3.70%
发文量
182
审稿时长
1.5 months
期刊介绍: Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals.
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