{"title":"重复测量 COVID-19 抗体诱发常见变异性免疫缺陷症 (CVID)：病例报告","authors":"Haruna Yamaki , Yoshihiro Miyashita , Shunya Hanawa , Shuichiro Ide , Makoto Kawaguchi , Hiroaki Kobayashi , Toshiharu Tsutsui , Yumiko Kakizaki , Yosuke Hirotsu , Masao Omata , Tomohiro Morio , Yasunari Miyazaki","doi":"10.1016/j.hmedic.2024.100082","DOIUrl":null,"url":null,"abstract":"<div><p>A 43-year-old female who was diagnosed with coronavirus disease 2019 (COVID-19) seventeen days before was transferred to our hospital because of fever and cough.Computed tomography (CT) showed consolidations in both lung fields, and we diagnosed COVID-19 pneumonia. After the addition of remdesivir and baricitinib, her symptoms improved. However, on day 19 a fever was observed, and CT also showed new consolidations. Genomic analysis revealed a different type from the first infection.Furthermore, repeated measurement of antibodies against SARS-CoV-2 revealed no antibody production. She was diagnosed with immunodeficiency and recovered completely with the use of immunoglobulins and antibody preparations for COVID-19. We report that repeated measurement of antibodies against SARS-CoV-2 revealed immunodeficiency disease.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"6 ","pages":"Article 100082"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949918624000470/pdfft?md5=25551138305ed261c2e096362193da37&pid=1-s2.0-S2949918624000470-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Repeated measurement of antibody for COVID-19 evoked having common variable immunodeficiency (CVID): Case report\",\"authors\":\"Haruna Yamaki , Yoshihiro Miyashita , Shunya Hanawa , Shuichiro Ide , Makoto Kawaguchi , Hiroaki Kobayashi , Toshiharu Tsutsui , Yumiko Kakizaki , Yosuke Hirotsu , Masao Omata , Tomohiro Morio , Yasunari Miyazaki\",\"doi\":\"10.1016/j.hmedic.2024.100082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A 43-year-old female who was diagnosed with coronavirus disease 2019 (COVID-19) seventeen days before was transferred to our hospital because of fever and cough.Computed tomography (CT) showed consolidations in both lung fields, and we diagnosed COVID-19 pneumonia. After the addition of remdesivir and baricitinib, her symptoms improved. However, on day 19 a fever was observed, and CT also showed new consolidations. Genomic analysis revealed a different type from the first infection.Furthermore, repeated measurement of antibodies against SARS-CoV-2 revealed no antibody production. She was diagnosed with immunodeficiency and recovered completely with the use of immunoglobulins and antibody preparations for COVID-19. We report that repeated measurement of antibodies against SARS-CoV-2 revealed immunodeficiency disease.</p></div>\",\"PeriodicalId\":100908,\"journal\":{\"name\":\"Medical Reports\",\"volume\":\"6 \",\"pages\":\"Article 100082\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2949918624000470/pdfft?md5=25551138305ed261c2e096362193da37&pid=1-s2.0-S2949918624000470-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949918624000470\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949918624000470","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Repeated measurement of antibody for COVID-19 evoked having common variable immunodeficiency (CVID): Case report
A 43-year-old female who was diagnosed with coronavirus disease 2019 (COVID-19) seventeen days before was transferred to our hospital because of fever and cough.Computed tomography (CT) showed consolidations in both lung fields, and we diagnosed COVID-19 pneumonia. After the addition of remdesivir and baricitinib, her symptoms improved. However, on day 19 a fever was observed, and CT also showed new consolidations. Genomic analysis revealed a different type from the first infection.Furthermore, repeated measurement of antibodies against SARS-CoV-2 revealed no antibody production. She was diagnosed with immunodeficiency and recovered completely with the use of immunoglobulins and antibody preparations for COVID-19. We report that repeated measurement of antibodies against SARS-CoV-2 revealed immunodeficiency disease.
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