Michael Weiner, Ziyue Liu, Jonathan Schelfhout, Paul Dexter, Anna R Roberts, Ashley Griffith, Vishal Bali, Jessica Weaver
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引用次数: 0
摘要
背景：慢性咳嗽（CC）影响着约 10% 的成年人，但人们对慢性咳嗽患者使用阿片类药物的情况还不甚了解：利用电子健康记录确定慢性咳嗽患者使用含阿片类止咳药（OCCS）处方的情况：设计：回顾性队列研究：通过对美国中西部地区的电子健康记录、诊断、处方和自然语言处理进行回顾性分析，确定了CC（至少有三次咳嗽就诊经历，第一次和最后一次就诊间隔56-120天）和 "非慢性队列"。研究采用了学生 t 检验、皮尔逊卡方检验和零膨胀泊松模型：结果：在23210名CC患者中，约20%的患者开具了OCCS处方；CC患者开具OCCS处方的几率是其他患者的两倍。在CC中，38%的医疗补助保险患者和15%的商业保险患者开具了OCCS药物处方：研究结果表明，阿片类药物在CC中发挥着重要作用，我们有机会进一步了解这些药物的有效性。
Prescriptions of opioid-containing drugs in patients with chronic cough.
Background: Chronic cough (CC) affects about 10% of adults, but opioid use in CC is not well understood.
Objectives: To determine the use of opioid-containing cough suppressant (OCCS) prescriptions in patients with CC using electronic health records.
Design: Retrospective cohort study.
Methods: Through retrospective analysis of Midwestern U.S. electronic health records, diagnoses, prescriptions, and natural language processing identified CC - at least three medical encounters with cough, with 56-120 days between first and last encounter - and a 'non-chronic cohort'. Student's t-test, Pearson's chi-square, and zero-inflated Poisson models were used.
Results: About 20% of 23,210 patients with CC were prescribed OCCS; odds of an OCCS prescription were twice as great in CC. In CC, OCCS drugs were ordered in 38% with Medicaid insurance and 15% with commercial insurance.
Conclusion: Findings identify an important role for opioids in CC, and opportunity to learn more about the drugs' effectiveness.
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