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引用次数: 0
摘要
DNA 和组蛋白上的共价修饰可调节真核基因的表达,通常被称为表观遗传修饰。这些化学反应需要各种代谢物作为供体或辅助底物,如乙酰辅酶 A、S-腺苷-l-蛋氨酸和α-酮戊二酸。发生在细胞质、细胞核或其他细胞区室的代谢过程可能会影响细胞核中的表观遗传修饰。在此,我们回顾了有关植物染色质修饰进而基因表达的代谢控制的最新进展,重点是 DNA 和组蛋白修饰中代谢过程和酶的核分区功能。此外,我们还讨论了细胞代谢在微调基因表达以促进植物对环境变化的反应或适应方面的功能。
Epigenetic control of gene expression by cellular metabolisms in plants
Covalent modifications on DNA and histones can regulate eukaryotic gene expression and are often referred to as epigenetic modifications. These chemical reactions require various metabolites as donors or co-substrates, such as acetyl coenzyme A, S-adenosyl-l-methionine, and α-ketoglutarate. Metabolic processes that take place in the cytoplasm, nucleus, or other cellular compartments may impact epigenetic modifications in the nucleus. Here, we review recent advances on metabolic control of chromatin modifications and thus gene expression in plants, with a focus on the functions of nuclear compartmentalization of metabolic processes and enzymes in DNA and histone modifications. Furthermore, we discuss the functions of cellular metabolisms in fine-tuning gene expression to facilitate the responses or adaptation to environmental changes in plants.
期刊介绍:
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.