预测巨大肝细胞癌患者预后的提名图和计算器。

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2024-08-01 Epub Date: 2024-06-17 DOI:10.1080/14737140.2024.2369129

Wanjin Chen, Shengtao Cheng

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引用次数: 0

摘要

研究目的本研究旨在探讨影响巨大肝细胞癌（G-HCC）患者总生存期（OS）的因素，并建立一个用于评估G-HCC患者OS的提名图和基于互联网的OS计算器：研究设计和方法：在 SEER 数据库中检索了 2445 例 G-HCC 患者。通过单变量和多变量分析确定了影响G-HCC患者OS的独立变量，并建立了一个提名图和基于互联网的OS计算器。通过C指数、AUC曲线和校准曲线评估了提名图的准确性：结果：分级、手术、放疗、化疗、T分期、M分期、AFP和纤维化被认为是影响OS的独立变量。这些变量被纳入提名图模型和基于互联网的OS计算器，以评估G-HCC患者的OS。提名图的C指数和AUC均优于AJCC分期系统。同样，校准曲线显示实际生存率与基于提名图的生存率一致：结论：提名图和基于互联网的OS计算器在G-HCC患者预后评估的可靠性和便利性方面优于传统的AJCC分期系统，更有利于临床医生预测G-HCC患者的生存期并制定最佳治疗策略。

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Nomogram and calculator for predicting the prognosis of patients with giant hepatocellular carcinoma.

Objectives: This study aimed to explore the factors affecting the overall survival (OS) of giant hepatocellular carcinoma (G-HCC) patients and establish a nomogram and an Internet-based OS calculator for evaluating the OS of G-HCC patients.

Research design and methods: A total of 2445 G-HCC patients were searched in the SEER database. The independent variables affecting OS of G-HCC patients were determined by univariate and multivariate analyses, and a nomogram and Internet-based OS calculator were established. The accuracy of the nomogram was evaluated by the C-index, the AUC curve, and calibration curve.

Results: Grade, surgery, radiotherapy, chemotherapy, T-staging, M-staging, AFP, and fibrosis were identified as independent variables affecting OS. These variables were included in the nomogram model and Internet-based OS calculator to evaluate OS in G-HCC patients. The C-indices and AUC of the nomogram are better than AJCC-staging system. Similarly, the calibration curves revealed that the actual survival was consistent with nomogram-based survival.

Conclusion: The nomogram and Internet-based OS calculator are superior to the traditional AJCC-staging system in the reliability and convenience of prognosis assessment for G-HCC patients, which is more conducive for clinicians to predict the survival of G-HCC patients and make the best treatment strategy.

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.