Galina Balakirski, Noemi Gäbelein-Wissing, Silke C Hofmann
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引用次数: 0
摘要
日光性荨麻疹是一种罕见的特发性光皮肤病。根据目前的知识,其发病机制很可能是对紫外线(UV)辐射或可见光激活的自身抗原产生的 I 型过敏反应。由于许多患者病情严重,因此可能会严重影响患者的生活质量。相比之下,多形性光糜烂是一种非常常见的疾病,根据目前的数据,可以将其解释为对紫外线辐射诱导的光过敏原的 IV 型过敏反应。尽管持续暴露在阳光下,但由于皮损会愈合,患者的生活质量一般不会受到明显影响。这两种在临床和病理上截然不同的光敏性皮肤病有共同的诊断方法,即光刺激和重要的治疗方法(光硬化)。在此,我们将概述上述疾病的临床表现、发病机制、诊断和现有治疗方案。
[Solar urticaria and polymorphous light eruption].
Solar urticaria is a rare idiopathic photodermatosis. According to the current knowledge its pathogenesis is most likely based on an allergic type I reaction to an autoantigen activated by ultraviolet (UV) radiation or visible light. As many of the patients suffer from severe forms of the disease, it may therefore severely impair the quality of life of those affected. In contrast, polymorphous light eruption is a very common disease, which, according to the current data, can be interpreted as a type IV allergic reaction to a photoallergen induced by UV radiation. As the skin lesions heal despite continued sun exposure, the patients' quality of life is generally not significantly impaired. These two clinically and pathogenetically very different light dermatoses have shared diagnostics by means of light provocation and an important therapeutic option (light hardening). Herein, we present an overview of the clinical picture, pathogenesis, diagnosis and available treatment options for the above-mentioned diseases.