CD8+ T 细胞耐受：无法转化

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-06-11 DOI:10.1016/j.immuni.2024.05.014

Katharine E. Block, Stephen C. Jameson

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引用次数: 0

摘要

CD8+T细胞对自身抗原耐受性的形成和破坏机制仍不清楚。在本期《免疫》（Immunity）杂志上，Van Der Byl 等人的研究表明，耐受性 CD8+ T 细胞会迅速形成一种表观遗传和转录不同的细胞状态，并表现出受损的蛋白质翻译。打破耐受需要炎症和增加抗原暴露来增强 MYC 表达并恢复翻译。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CD8+ T cell tolerance: It doesn’t translate

The mechanisms that make and break CD8⁺ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8⁺ T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibit impaired protein translation. Breaking tolerance requires both inflammation and increased antigen exposure to augment MYC expression and restore translation.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.