Zhixuan Yu , Minghua Li , Ling Yang , Hao Liu , Guanyu Ding , Shuaining Ma , Ling Liu , Shaojun Dong
{"title":"促进糖尿病伤口愈合:具有清除 ROS 和不依赖 ROS 的抗菌特性的双管齐下方法","authors":"Zhixuan Yu , Minghua Li , Ling Yang , Hao Liu , Guanyu Ding , Shuaining Ma , Ling Liu , Shaojun Dong","doi":"10.1016/j.nantod.2024.102358","DOIUrl":null,"url":null,"abstract":"<div><p>The intricate microenvironment often hinders diabetic wounds from following a normal healing process, marked by prolonged low-grade inflammation, thereby slowing or stalling wound healing. Nanomedicine stands as a pivotal branch in the evolution of therapeutic strategies, yet grapples with inherent conflicting traits – the ROS-dependent antibacterial properties of most materials and the anti-inflammatory ROS-scavenging capabilities. This study introduces a multifunctional MOF-199/GO nanocomposite designed to promote diabetic wound healing by its robust ROS scavenging capacity, ROS-independent antibacterial and anti-biofilm properties, and the ability to modulate wound microenvironments. In a skin wound model on type I diabetes rats, the addition of MOF-199/GO efficiently orchestrates the healing process into the defined phases of inflammation, proliferation, and remodeling, achieving a remarkable 96 % wound closure by day 10. When employed as a drug, MOF-199/GO exhibits minimal biological toxicity <em>in vivo</em>. Moreover, when combined with various dressing materials, the drug’s performance remains unchanged, indicating its practical application value.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancing diabetic wound healing: A two-pronged approach with ROS scavenging and ROS-independent antibacterial properties\",\"authors\":\"Zhixuan Yu , Minghua Li , Ling Yang , Hao Liu , Guanyu Ding , Shuaining Ma , Ling Liu , Shaojun Dong\",\"doi\":\"10.1016/j.nantod.2024.102358\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The intricate microenvironment often hinders diabetic wounds from following a normal healing process, marked by prolonged low-grade inflammation, thereby slowing or stalling wound healing. Nanomedicine stands as a pivotal branch in the evolution of therapeutic strategies, yet grapples with inherent conflicting traits – the ROS-dependent antibacterial properties of most materials and the anti-inflammatory ROS-scavenging capabilities. This study introduces a multifunctional MOF-199/GO nanocomposite designed to promote diabetic wound healing by its robust ROS scavenging capacity, ROS-independent antibacterial and anti-biofilm properties, and the ability to modulate wound microenvironments. In a skin wound model on type I diabetes rats, the addition of MOF-199/GO efficiently orchestrates the healing process into the defined phases of inflammation, proliferation, and remodeling, achieving a remarkable 96 % wound closure by day 10. When employed as a drug, MOF-199/GO exhibits minimal biological toxicity <em>in vivo</em>. Moreover, when combined with various dressing materials, the drug’s performance remains unchanged, indicating its practical application value.</p></div>\",\"PeriodicalId\":395,\"journal\":{\"name\":\"Nano Today\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.2000,\"publicationDate\":\"2024-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Today\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1748013224002147\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224002147","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Enhancing diabetic wound healing: A two-pronged approach with ROS scavenging and ROS-independent antibacterial properties
The intricate microenvironment often hinders diabetic wounds from following a normal healing process, marked by prolonged low-grade inflammation, thereby slowing or stalling wound healing. Nanomedicine stands as a pivotal branch in the evolution of therapeutic strategies, yet grapples with inherent conflicting traits – the ROS-dependent antibacterial properties of most materials and the anti-inflammatory ROS-scavenging capabilities. This study introduces a multifunctional MOF-199/GO nanocomposite designed to promote diabetic wound healing by its robust ROS scavenging capacity, ROS-independent antibacterial and anti-biofilm properties, and the ability to modulate wound microenvironments. In a skin wound model on type I diabetes rats, the addition of MOF-199/GO efficiently orchestrates the healing process into the defined phases of inflammation, proliferation, and remodeling, achieving a remarkable 96 % wound closure by day 10. When employed as a drug, MOF-199/GO exhibits minimal biological toxicity in vivo. Moreover, when combined with various dressing materials, the drug’s performance remains unchanged, indicating its practical application value.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.