用于癌症免疫疗法透皮给药的溶解微针。

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2024-06-10 DOI:10.1039/D4TB00659C

Maya Xiang, Chunli Yang, Li Zhang, Siyi Wang, Ya Ren and Maling Gou

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引用次数: 0

摘要

免疫疗法是治疗癌症的一种重要方法。透皮给药是一种很有前景的免疫疗法。溶解微针主要由可溶性或可生物降解的聚合物制成，因其无痛、安全、方便、载药能力强、各种材料易得等优点而受到广泛关注，是一种理想的透皮给药系统。本综述全面总结了溶解微针的制备方法、材料以及在癌症疫苗、免疫检查点抑制剂和收养细胞疗法中的应用。此外，还讨论了与未来临床转化相关的挑战和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

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Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

Immunotherapy is an important approach in cancer treatment. Transdermal administration is emerging as a promising method for delivering immunotherapeutics. Dissolving microneedles are made mainly of soluble or biodegradable polymers and have garnered widespread attention due to their painlessness, safety, convenience, excellent drug loading capacity, and easy availability of various materials, making them an ideal transdermal delivery system. This review comprehensively summarized the preparation methods, materials, and applications of dissolving microneedles in cancer vaccines, immune checkpoint inhibitors, and adoptive cell therapy. Additionally, the challenges and perspectives associated with their future clinical translation are discussed.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices