构建大脑马赛克：扩展视角。

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-09-01 Epub Date: 2024-06-08 DOI:10.1016/j.tig.2024.05.008

Sahibjot Sran, Amanda Ringland, Tracy A Bedrosian

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引用次数: 0

摘要

大脑的复杂性与它作为基因镶嵌体的性质密切相关，其中每个细胞都有独特的体细胞变异群，这些变异促成了功能和表型的多样性。在神经发生过程中产生的后代变异被认为是大脑马赛克的关键因素；然而，最近的研究进展拓宽了我们的认识，将从胚胎发生到衰老的整个生命周期中神经基因组多样性的来源也包括在内。在这篇综述中，我们将超越神经发育的传统局限，深入探讨导致大脑马赛克的各种来源的复杂机制。

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Building the brain mosaic: an expanded view.

The complexity of the brain is closely tied to its nature as a genetic mosaic, wherein each cell is distinguished by a unique constellation of somatic variants that contribute to functional and phenotypic diversity. Postzygotic variation arising during neurogenesis is recognized as a key contributor to brain mosaicism; however, recent advances have broadened our understanding to include sources of neural genomic diversity that develop throughout the entire lifespan, from embryogenesis through aging. Moving beyond the traditional confines of neurodevelopment, in this review, we delve into the complex mechanisms that enable various origins of brain mosaicism.

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.