L D Jiménez-Posada, A F Palacio-Sánchez, Y J Montagut-Ferizzola, M Ardila-Villegas, Juan C Maya
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Validation of Math Model Using Porous Media for Determining Alveolar CO 2 in Ventilated Patients.
Objectives: To validate a mathematical model using porous media theory for alveolar CO2 determination in ventilated patients.
Design: Mathematical modeling study with prospective clinical validation to simulate CO2 exchange from bloodstream to airway entrance.
Setting: ICU.
Patients: Thirteen critically ill patients without chronic or acute lung disease.
Interventions: None.
Measurements and main results: Model outcomes compared with patient data showed correlations for end-tidal CO2 (EtCO 2 ), area under the CO2 curve, and Pa CO2 of 0.918, 0.954, and 0.995. Determination coefficients ( R2 ) were 0.843, 0.910, and 0.990, indicating precision and predictive power.
Conclusions: The mathematical model shows potential in pulmonary critical care. Although promising, practical application demands further validation, clinician training, and patient-specific adjustments. The path to clinical use will be iterative, involving validation and education.
期刊介绍：
Critical Care Medicine is the premier peer-reviewed, scientific publication in critical care medicine. Directed to those specialists who treat patients in the ICU and CCU, including chest physicians, surgeons, pediatricians, pharmacists/pharmacologists, anesthesiologists, critical care nurses, and other healthcare professionals, Critical Care Medicine covers all aspects of acute and emergency care for the critically ill or injured patient.
Each issue presents critical care practitioners with clinical breakthroughs that lead to better patient care, the latest news on promising research, and advances in equipment and techniques.
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