肿瘤浸润淋巴细胞密度的预后价值及其与结肠腺癌临床形态特征的关系。

B Shkurupii, L Zakhartseva
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引用次数: 0

摘要

目的:研究结肠腺癌(CAC)中肿瘤浸润淋巴细胞(TILs)密度的预后价值及其与其他临床形态学参数的关联。TILs密度按TILs占肿瘤基质面积的百分比估算。根据 TILs 密度指数,将患者分为 3 组:TILs 0-9%(88 人);TILs 10-39%(106 人);TILs >40%(42 人)。根据这一指标,对他们的总生存期(OS)进行分析:Kaplan - Meier曲线显示,不同TILs浸润强度的患者的OS差异显著(P < 0.001)。多变量考克斯比例危险回归模型分析证实,与低TILs密度相比,中度TILs密度(HR 0.57,95% CI 0.34-0.96,p = 0.035)患者的OS率更高。TILs与分期(p < 0.001)、淋巴结转移pN(p < 0.001)、远处转移M(p < 0.001)和患者预后(p < 0.001)相关:结论:TILs可作为常规组织学检查的额外预后工具,并与CAC最重要的临床形态特征密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PROGNOSTIC VALUE OF THE DENSITY OF TUMOR-INFILTRATING LYMPHOCYTES AND ITS ASSOCIATION WITH CLINICAL-MORPHOLOGICAL FEATURES OF COLON ADENOCARCINOMAS.

Aim: To study the prognostic value of the density of tumor-infiltrating lymphocytes (TILs) and its association with other clinical-morphological parameters in colon adenocarcinomas (CAC).

Materials and methods: 236 CAC samples were examined. TILs density was estimated as the percentage of tumor stromal area occupied by TILs. By the index of TILs density, the patients were divided into 3 groups: TILs 0-9% (n = 88); TILs 10-39% (n = 106); TILs > 40% (n = 42). Dependent on this index, their overall survival (OS) was analyzed.

Results: Kaplan - Meier curves revealed a significant (p < 0.001) difference in the OS for patients with different TILs infiltration intensities. Multivariate Cox's proportional hazard regression model analysis has confirmed that patients with moderate TILs density (HR 0.57, 95% CI 0.34-0.96, p = 0.035) had better OS rates compared to low TILs density. TILs were associated with the stage (p < 0.001), lymph node metastasis pN (p < 0.001), distant metastasis M (p < 0.001), and the patient's outcome (p < 0.001).

Conclusion: TILs can be considered an additional prognostic tool during regular histological examination and are strongly associated with the most significant clinical-morphological features of CAC.

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