红树林相关真菌毛霉 SCNU-F0048 的新类固醇。

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2024-06-06 DOI:10.1016/j.steroids.2024.109449

Chen Chen, Lingling Liu, Siyao Ye, Jialin Li, Li Wu, Junsen Li, Hao Jia, Yuhua Long

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引用次数: 0

摘要

对毛霉菌 SCNU-F0048 的化学研究发现了两种新的类固醇，即麦角甾-4,6,8(14),22-四烯-3-酮（3'-甲基-4'-羟基-γ-丁烯内酯）（1）和樟脑甾醇 B（2），以及两种已知的化合物，即麦角甾-4,6,8(14),22-四烯-3-酮（3）和 4-羟基-17-甲基辛甾醇（4）。即石杉碱甲-4,6,8(14),22-四烯-3-酮（3）和 4-羟基-17-甲基紫杉醇（4）。通过广泛的核磁共振、光谱分析和单晶 X 射线衍射分析，这些化合物的结构得以阐明。生物测定显示，化合物 1 对一组肿瘤细胞株具有很强的细胞毒性。此外，化合物 1 和 2 对意大利青霉具有极佳的抗真菌活性，其 IC50 值分别为 0.016 和 0.022 μM。

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New steroids from mangrove-associated fungus Trichoderma asperellum SCNU-F0048

Chemical investigation of the fungus Trichoderma asperellum SCNU-F0048 led to the discovery of two new steroids, ergosta-4,6,8 (14),22-tetraen-3-(3′-methyl-4′-hydroxyl-γ-butenolide) (1) and camphosterol B (2), as well as two known compounds, i.e. stigmasta-4,6,8(14),22-tetraen-3-one (3) and 4-hydroxy-17- methylincisterol (4). Their structures were elucidated by extensive nuclear mangnetic resonance, spectrum analysis and single crystal X-ray diffraction analysis. Bioassay disclosed that compound 1 showed strong cytotoxicity to a panel of tumor cell lines. Moreover, compounds 1 and 2 showed excellent antifungal activity against Penicillium italicum with IC₅₀ values of 0.016 and 0.022 μM, respectively.

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.